773887-07-3Relevant academic research and scientific papers
OGA INHIBITOR COMPOUNDS
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Page/Page column 47, (2021/06/26)
The present invention relates to O-GlcNAc hydrolase (OGA) inhibitors. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and
Heteroaryl substituted 1, 2, 4-triazin-3-amine derivative , preparation method and application thereof in medicine
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Paragraph 0373; 0375; 0376; 0377; 0378, (2018/09/26)
The present invention relates to a heteroaryl substituted 1, 2, 4-triazin-3-amine derivative, a preparation method thereof and an application thereof in medicine. In particular, the invention relatesto the heteroaryl substituted 1, 2, 4-triazin-3-amine de
Synthesis of novel diarylpyrimidine analogues of TMC278 and their antiviral activity against HIV-1 wild-type and mutant strains
Mordant, Celine,Schmitt, Benoit,Pasquier, Elisabeth,Demestre, Christophe,Queguiner, Laurence,Masungi, Chantal,Peeters, Anik,Smeulders, Liesbeth,Bettens, Eva,Hertogs, Kurt,Heeres, Jan,Lewi, Paul,Guillemont, Jerome
, p. 567 - 579 (2008/02/10)
Novel diarylpyrimidines (DAPY), which represent next generation of non-nucleoside reverse transcriptase inhibitors (NNRTIs), were synthesized and their activities against human immunodeficiency virus type I (HIV-1) assessed. Modulations at positions 2 and
SUBSTITUTED ISOQUINOLINONES
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Page/Page column 80, (2010/02/11)
Isoquinolinone compounds are provided that are useful for the inhibition of ADP-platelet aggregation, particularly in the treatment of thrombosis and thrombosis related conditions or disorders.
Calcitonin gene related peptide receptor antagonists
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, (2008/06/13)
The present invention relates to compounds of Formula (I) as antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their use in therapy for treatment of neurogenic vasodilation, neurogenic inflammation, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.
