773887-29-9Relevant academic research and scientific papers
Tandem epoxide or aziridine ring opening by azide/copper catalyzed [3+2] cycloaddition: Efficient synthesis of 1,2,3-triazolo β-hydroxy or β-tosylamino functionality motif
Kumaraswamy, Gullapalli,Ankamma, Kukkadapu,Pitchaiah, Arigala
, p. 9822 - 9825 (2007)
(Chemical Equation Presented) A novel and practical procedure for the synthesis of small molecules possessing β-hydroxy or N-tosylamino 1,2,3-triazole motif by azidation of epoxides or N-tosylaziridines with sodium azide followed by "click reaction" using
Iron(ii)-catalyzed intermolecular aziridination of alkenes employing hydroxylamine derivatives as clean nitrene sources
Berhal, Farouk,Grimaud, Laurence,Kirby, Georgina,Prestat, Guillaume,Vitale, Maxime R.
, p. 9428 - 9432 (2021/12/09)
The iron-catalyzed intermolecular aziridination of alkenes with hydroxylamine derivatives is described. Using simple iron(ii) sources and readily available ligands, the formal (2 + 1) cycloaddition process proved to be efficient on both styrenes and aliphatic alkenes, providing access to a wide range of aziridines. In these particularly sustainable reaction conditions, yields up to 89% could be obtained, with a catalyst loading which could be lowered to 5 mol% when the reaction was performed on large scale. Preliminary mechanistic studies suggest that both concerted and stepwise pathways are operating in this transformation. This journal is
