774-22-1 Usage
Uses
Used in Dye and Pigment Synthesis:
N-Ethyl-4-Fluoro-2-Nitroaniline is used as an intermediate in the synthesis of dyes and pigments for various applications. Its unique chemical structure allows for the creation of a wide range of colors and properties in the resulting dyes and pigments.
Used in Chemical Manufacturing:
As an intermediate, N-Ethyl-4-Fluoro-2-Nitroaniline is utilized in the manufacture of other substances, contributing to the production of various chemical products. Its presence in the synthesis process can influence the properties and performance of the final products.
Used in Pharmaceutical Industry:
N-Ethyl-4-Fluoro-2-Nitroaniline may also be used in the pharmaceutical industry as a building block for the development of new drugs. Its unique structure and functional groups can be leveraged to create compounds with specific therapeutic properties.
Used in Research and Development:
In the field of research and development, N-Ethyl-4-Fluoro-2-Nitroaniline can be employed as a starting material for the exploration of new chemical reactions and the synthesis of novel compounds. Its reactivity and functional groups make it a valuable tool for advancing scientific knowledge and discovering new applications.
Safety Measures:
Due to the potential reactivity of N-Ethyl-4-Fluoro-2-Nitroaniline, it is crucial to implement safety measures during its handling and use. This includes wearing appropriate personal protective equipment, such as gloves, goggles, and respirators, to minimize the risk of exposure to eyes, skin, and respiratory systems. Additionally, proper storage and disposal methods should be followed to prevent accidental release or contamination.
Check Digit Verification of cas no
The CAS Registry Mumber 774-22-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,7 and 4 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 774-22:
(5*7)+(4*7)+(3*4)+(2*2)+(1*2)=81
81 % 10 = 1
So 774-22-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H9FN2O2/c1-2-10-7-4-3-6(9)5-8(7)11(12)13/h3-5,10H,2H2,1H3
774-22-1Relevant academic research and scientific papers
1- Or 3-(3-amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2- ones: Potent, selective, and orally efficacious norepinephrine reuptake inhibitors
Zhang, Puwen,Terefenko, Eugene A.,Bray, Jenifer,Deecher, Darlene,Fensome, Andrew,Harrison, Jim,Kim, Callain,Koury, Elizabeth,Mark, Lilly,McComas, Casey C.,Mugford, Cheryl A.,Trybulski, Eugene J.,Vu, An T.,Whiteside, Garth T.,Mahaney, Paige E.
experimental part, p. 5703 - 5711 (2010/02/28)
Sequential structural modifications of the aryloxypropanamine template (e.g., atomoxetine, 2) led to a novel series of 1-(3-amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors (NRIs). In general, this series of compounds potently blocked the human norepinephrine transporter (hNET) while exhibiting selectivity at hNET against both the human serotonin (hSERT) and dopamine transporters (hDAT). Numerous compounds (e.g., 19-22) had low nonamolar hNET potency with IC 50 values of 7-10 nM and excellent selectivity (>500 fold) at hNET over hSERT and hDAT. Several compounds, such as 20 and 22, were tested in a telemetric rat model of ovariectomized-induced thermoregulatory dysfunction and were efficacious at oral doses of 3 mg/kg in reducing the tail skin temperature. In addition, compound 20 was also studied in the rat hot plate and spinal nerve ligation (SNL) models of acute and neuropathic pain, respectively, and was orally efficacious at doses of 3-10 mg/kg.
