77420-74-7

Upstream product

• 77420-68-9 N-[1-(4-Bromo-phenyl)-meth-(E)-ylidene]-N'-[1-phenyl-1-thiocyanato-meth-(Z)-ylidene]-hydrazine 
• 2002-03-1 2-amino-5-phenyl-1,3,4-thiadiazole 
• 1122-91-4 4-bromo-benzaldehyde 
• 93-89-0 benzoic acid ethyl ester 
• 613-94-5 benzoic acid hydrazide 
• 77420-50-9 4-(4-bromophenyl)-1-chloro-1-phenyl-2,3-diazabutadiene 
• 59394-93-3 N'-(4-bromorobenzylidene)benzohydrazide 

Downstream Products

• 80517-10-8 2-(4-bromophenyl)-3-(5-phenyl-1,3,4-thiadiazol-2-yl)thiazolidin-4-one 

Relevant academic research and scientific papers

Synthesis of some new arylidenes-substituted phenyl-1,3,4-thiadiazol-4-oxo- Thiazolidines: Antimicrobial and diuretic activities

A series of new [2-(substituted aryl)-3-{5-(substituted phenyl)-1,3,4-thiadiazol}]-4-oxo-thiazolidines, 3(a- o) have been synthesized via the condensation of 5-(substituted phenyl)-2-(2-substituted benzylidene amino)-1,3,4- thiadiazoles, 2(a-o) with thioglycolic acid. The compounds 2(a-o) were synthesized from 5-(substituted phenyl)-2- amino-1,3,4-thiadiazole, 1(a-c) with various aromatic aldehydes which itself was prepared from substituted aromatic acid(s) using thiosemicarbazide. The compounds 3(a-o) on treatment with various aromatic aldehydes afforded [5- (substituted arylidenes)-2-(substituted aryl)-3-{5-(substituted phenyl)-1,3,4-thiadiazol}]-4-oxo-thiazolidines, 4(a-o). The structures of all the synthesized compounds have been determined by spectral and chemical methods. The compounds 2, 3 and 4 were screened for their antifungal and antibacterial activities against E. coli, S. typhimurium and B. subtilis bacteria and R. oryzae, C. albicans and A. niger fungi and diuretic activity on adult male rats.

Synthesis of Some Azomethine Derivatives of 2-Amino-5-phenyl-1,3,4-thiadiazole

Azomethines derived from 2-amino-5-phenyl-1,3,4-thiadiazole were prepared by fusion of the starling amine with corresponding carhonyl compound. The method ensures yields of target products up to 97%. The composition and structure of the products were conf

Unsaturated Compounds containing Nitrogen. Part 4. Further Reactions of 1-Chloro-2,3-diazabutadienes with S-Nucleophiles

1-Chloro-1,4-diaryl-2,3-diazabutadienes (Ar1CCl=NN=CHAr2), prepared by the reaction of thionyl chloride with aroylhydrazones (Ar1CONHN=CHAr2), react with thiosemicarbazide or thiocarbohydrazide to give 2-arylidenehydrazino-5-aryl-1,3,4-thiadiazoles, and with potassium thiocyanate to give 1-thiocyanato-1,4-diaryl-2,3-diazabutadienes which isomerize thermally to arylideneamino-5-aryl-1,3,4-thiadiazoles. 1-Chloro-1,4-diphenyl-2,3-diazabutadiene reacts with potassium ethylxanthate to give a 1-ethylxanthyl-2,3-diazabutadiene which on pyrolysis yields 2,5-diphenyl-1,3,4-thiadiazole.