774214-08-3

Upstream product

• 64269-79-0 Carbonyldiimidazole 
• 774214-11-8 tert-butyl (2-bromo-6-cyano-3-cyclohexyl-1H-indol-1-yl)acetate 
• 774214-10-7 2-bromo-3-cyclohexyl-1H-indole-6-carbonitrile 
• 494799-76-7 2-bromo-3-cyclohexyl-1H-indole-6-carboxylic acid 
• 494799-19-8 methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate 
• 774214-12-9 tert-butyl [2-bromo-3-cyclohexyl-6-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1H-indol-1-yl]acetate 
• 98-80-6 phenylboronic acid 

Relevant academic research and scientific papers

Development of carboxylic acid replacements in indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase

Allosteric inhibition of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase enzyme has recently emerged as a viable strategy toward blocking replication of viral RNA in cell-based systems. We report here 2 series of indole-N-acetamides, bearing

INDOLE ACETAMIDES AS INHIBITORS OF THE HEPATITIS C VIRUS NS5B POLYMERASE

The present invention relates to indole and azaindole compounds of formula (I): wherein X1, X2, X3, X4, A1, Ar1, R1, R2 and n are as defined herein, and pharmaceutically acceptable salts thereof, useful in the prevention and treatment of hepatitis C infections.