77422-60-7Relevant academic research and scientific papers
AN EFFICIENT AND FLEXIBLE APPROACH FOR THE SYNTHESIS OF 4-DEMETHOXY-DAUNOMYCINONE AND 4-DEMETHOXY-11-DEOXYDAUNOMYCINONE
Rao, A. V. Rama,Mehendale, A. R.,Reddy, K. Bal
, p. 1093 - 1096 (2007/10/02)
A flexible and common approach for the synthesis of aglycones of the biologically active antitumor anthracyclines has been described.
Simple o-Quinodimethane Route to (+/-)-4-Demethoxydaunomycinone
Kerdesky, Francis A.,Ardecky, Robert J.,Lakshmikantham, M. V.,Cava, Michael P.
, p. 1992 - 1996 (2007/10/02)
The anthracycline antibiotics daunorubicin and adriamycin are important clinically useful drugs in the treatment of a number of human cancers.The structurally simplified synthetic analogues 4-demethoxydaunorubicin and 4-demethoxyadriamycin show much clinical promise.The synthesis of the corresponding aglycon (+/-)-4-demethoxydaunomycinone from the inexpensive dye intermediate quinizarin, utilizing o-quinodimethane intermediates, is discussed.
