77423-07-5

Upstream product

• 76745-48-7 4,9-dihydro-5-methoxy-9-oxopyrazolo<5,1-b>quinazoline-2-carboxylic acid 
• 34954-65-9 3-methoxyisatoic anhydride 
• 76745-47-6 3-methoxyanthranilic hydrazide 
• 3177-80-8 2-amino-3-methoxybenzoic acid 

Downstream Products

• 76745-70-5 4,9-dihydro-5-methoxy-9-oxopyrazolo<5,1-b>quinazoline-2-carboxnitrile 

Relevant academic research and scientific papers

Pyrazoloquinazolin-9-ones: A New Series of Antiallergic Agents

A new series of antiallergic agents, pyrazoloquinazolin-9-ones, was synthesized and evaluated for inhibitory effects in the rat reaginic passive cutaneous anaphylaxis (PCA) screen.Several analogues were found to be more potent than cromolyn sodium intravenously.Structure-activity relationships are discussed.One of the compounds, 4,9-dihydro-5-methoxy-9-oxopyrazoloquinazoline-2-carboxylic acid (36), was found to be approximately 250 times more potent than cromolyn sodium intravenously.

Pyrazolo[5,1-b]quinazolin-9-(4H)-ones and anti-allergic pharmaceutical compositions containing them

Certain pyrazolo[5,1-b]quinazolin-9-(4H)-ones are disclosed. These compounds prevent the allergic response in mammals. Novel alkylthioanthranilic acids, useful as intermediates, are also disclosed.