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(R)-b-Amino-3-fluorobenzenepropanol is a chiral compound with a 3-fluorobenzenepropanol core structure, derived from the amino acid phenylalanine. It is a potent and selective dopamine D2 receptor agonist, which has been studied for its potential use in the treatment of various neurological and psychiatric disorders.

774243-59-3

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774243-59-3 Usage

Uses

Used in Pharmaceutical Industry:
(R)-b-Amino-3-fluorobenzenepropanol is used as a therapeutic agent for the treatment of neurological disorders such as Parkinson's disease and schizophrenia. Its application is based on its ability to modulate dopamine receptors, which play a crucial role in these conditions.
Used in Pain Management:
(R)-b-Amino-3-fluorobenzenepropanol is used as an analgesic agent due to its potential to alleviate pain. The exact mechanism of action is still under investigation, but its interaction with the dopamine system may contribute to its pain-relieving properties.
Used in Antipsychotic Treatment:
(R)-b-Amino-3-fluorobenzenepropanol is used as an antipsychotic agent, which may help in managing the symptoms of psychiatric disorders. Its efficacy in this application is attributed to its modulation of dopamine receptors, which are often dysregulated in such conditions.
Used in Drug Development:
(R)-b-Amino-3-fluorobenzenepropanol is used as a lead compound in the development of new pharmaceuticals targeting the dopamine system. Its selective agonist activity makes it a promising candidate for creating novel treatments for a range of conditions related to dopamine dysregulation.

Check Digit Verification of cas no

The CAS Registry Mumber 774243-59-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,7,4,2,4 and 3 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 774243-59:
(8*7)+(7*7)+(6*4)+(5*2)+(4*4)+(3*3)+(2*5)+(1*9)=183
183 % 10 = 3
So 774243-59-3 is a valid CAS Registry Number.

774243-59-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (R)-2-amino-3-(3-fluorophenyl)-1-propanol

1.2 Other means of identification

Product number -
Other names (R)-b-Amino-3-fluorobenzenepropanol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:774243-59-3 SDS

774243-59-3Relevant academic research and scientific papers

Biosynthesis of Fluorinated Peptaibols Using a Site-Directed Building Block Incorporation Approach

Rivera-Chávez, José,Raja, Huzefa A.,Graf, Tyler N.,Burdette, Joanna E.,Pearce, Cedric J.,Oberlies, Nicholas H.

supporting information, p. 1883 - 1892 (2017/06/28)

Synthetic biological approaches, such as site-directed biosynthesis, have contributed to the expansion of the chemical space of natural products, making possible the biosynthesis of unnatural metabolites that otherwise would be difficult to access. Such m

Structure-based design of novel human Pin1 inhibitors (I)

Guo, Chuangxing,Hou, Xinjun,Dong, Liming,Dagostino, Eleanor,Greasley, Samantha,Ferre, RoseAnn,Marakovits, Joseph,Johnson, M. Catherine,Matthews, David,Mroczkowski, Barbara,Parge, Hans,VanArsdale, Todd,Popoff, Ian,Piraino, Joseph,Margosiak, Stephen,Thomson, James,Los, Gerrit,Murray, Brion W.

scheme or table, p. 5613 - 5616 (2010/04/30)

Pin1 is a member of the cis-trans peptidyl-prolyl isomerase family with potential anti-cancer therapeutic value. Here we report structure-based de novo design and optimization of novel Pin1 inhibitors. Without a viable lead from internal screenings, we de

Phosphate/sulfate ester compounds and pharmaceutical composition for inhibiting protein interacting NIMA (PIN1)

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Page/Page column 40; 62-63, (2010/02/14)

Phosphate/sulfate ester compounds that modulate and/or inhibit the activity of protein interacting NIMA (PIN1), and to pharmaceutical compositions containing such compounds are described. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating disorders characterized by hypertension, inappropriate cell proliferation, infectious diseases, and neurodegenerative brain disorders, by administering effective amounts of such compounds.

PHOSPHATE/SULFATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PROTEIN INTERACTING NIMA (PIN1)

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Page 62, (2010/02/08)

Phosphate/sulfate ester compounds that modulate and/or inhibit the activity of protein interacting NIMA (PIN1), and to pharmaceutical compositions containing such compounds are described. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating disorders characterized by hypertension, inappropriate cell proliferation, infectious diseases, and neurodegenerative brain disorders, by administering effective amounts of such compounds.

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