77425-65-1

Upstream product

• 84838-26-6 (2S,3R)-N¹,N¹,N⁴,N⁴-Tetraethyl-2-((S)-hydroxy-phenyl-methyl)-3-((R)-hydroxy-phenyl-methyl)-succinamide 
• 140-10-3 (E)-3-phenylacrylic acid 
• 114125-21-2 (3S,4S)-3,4-Bis-(phenyl-trimethylsilanyloxy-methyl)-dihydro-thiophene-2,5-dione 
• 77220-06-5 2,5-bis<(trimethylsilyl)oxy>furan 
• 100-52-7 benzaldehyde 
• 141-05-9 Diethyl maleate 
• 624-48-6 dimethyl cis-but-2-ene-1,4-dioate 

Relevant academic research and scientific papers

Reductive Bis-addition of Aromatic Aldehydes to α,β-Unsaturated Esters via the Use of Sm/Cu(I) in Air: A Route to the Construction of Furofuran Lignans

The novel bis-addition of benzaldehydes to acrylates or maleates was achieved by the direct use of samarium metal with the assistance of CuI under mild conditions under dry air, and the useful 2-hydroxylalkyl-γ-butyrolactons and lignan derivatives were thus constructed with high efficiency. The key factors that influence the reaction efficiency were investigated. The use of potassium iodide and molecular sieves as additives can improve the reaction efficiency remarkably.

Stereochemistry of phellinsin A: A concise synthesis of α-arylidene-γ-lactones

Phellinsin A (1a) was prepared in a concise way, thereby elucidating the relative stereochemistry of the aryl and carboxylic acid groups in 1a. The synthesis employed selective monohydrolysis of the dilactones derived from oxidative dimerization of cinnamic acid derivatives. This approach provided a practical synthetic route to α-arylidene-γ-lactones. Copyright Taylor & Francis, Inc.

Reactions of Trialkylsilyl Trifluoromethanesulfonates, XII. - Aldol-Type Reactions with 2,6-Bis(trimethylsilyloxy)thiophene Synthesis of Bicyclic γ-Lactones

In the presence of trimethylsilyl triflate (2) aromatic aldehydes 4 react with 2,6-bis(trimethylsilyloxy)thiophene (3) to yield the 3,4-disubstituted thiosuccinic anhydrides 5.By hydrolysis of the products 5 in the presence of lead acetate the diaryl-subs

DIMETALATED TERTIARY SUCCINAMIDES. SYNTHESIS OF SEVERAL CLASSES OF LIGNANS INCLUDING THE MAMMALIAN URINARY LIGNANS ENTEROLACTONE AND ENTERODIOL

Reaction of dimetalated succinamides with benzyl halides and aromatic aldehydes provides short routes to diverse lignan natural products 2, 3, and 4a, including the human urinary metabolites (3d) and (2e).

CHEMISTRY OF 2,5-BIS(TRIMETHYLSILOXY)FURANS. II: REACTIONS WITH CARBONYL COMPOUNDS AND THE SYNTHESIS OF 2,6-DIARYL-3,7-DIOXABICYCLOOCTANE-4,8-DIONES

2,5-Bis(trimethylsiloxy)furan reacted with a number of substituted benzaldehydes under activation of titan tetrachloride to give 2,6-diaryl-3,7-dioxabicyclooctane-4,8-diones.