77429-04-0

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
Ethyl (2E)-3-chloro-2-cyano-4,4,4-trifluorobut-2-enoate is used as a precursor in the synthesis of pharmaceuticals and agrochemicals. Its unique chemical structure allows it to be a versatile building block for the development of new drugs and pesticides.
Used as a Solvent in Chemical Reactions:
Ethyl (2E)-3-chloro-2-cyano-4,4,4-trifluorobut-2-enoate is also used as a solvent in various chemical reactions. Its low toxicity and good solubility in organic solvents make it a suitable choice for a range of applications.
Safety Precautions:
It is important to handle ethyl (2E)-3-chloro-2-cyano-4,4,4-trifluorobut-2-enoate with caution as it can be harmful if inhaled or ingested, and can cause irritation to the skin and eyes. Proper safety measures should be taken during its use and storage.

Upstream product

• 105-56-6 ethyl 2-cyanoacetate 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 133922-58-4 ethyl 5-amino-3-trifluoromethyl-1H-pyrazole-4-carboxylate 
• 77429-15-3 1-phenyl-3-trifluoromethyl-4-ethoxycarbonyl-5-aminopyrazole 
• 77429-08-4 1-cyano-1-ethoxycarbonyl-2-anilino-2-trifluoromethylethylene 

Relevant academic research and scientific papers

N-(4-(AZAINDAZOL-6-YL)-PHENYL)-SULFONAMIDES AND THEIR USE AS PHARMACEUTICALS

N-(4-(Azaindazol-6-yl)-phenyl)-sulfonamides and their use as pharmaceuticals The present invention relates to N-(4-(azaindazol-6-yl)-phenyl)-sulfonamides of the formula I, wherein Ar, n, X, Z, R1, R2 and R3 have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds which modulate protein kinase activity, specifically the activity of serum and glucocorticoid regulated kinase (SGK), in particular of serum and glucocorticoid regulated kinase isoform 1 (SGK-1, SGK1), and are suitable for the treatment of diseases in which SGK activity is inappropriate, for example degenerative joint disorders or inflammatory processes such as osteoarthritis or rheumatism. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use as pharmaceuticals, and pharmaceutical compositions comprising them.

Synthesis of trifluoromethyl-promoted functional pyrazolo[1,5-a]pyrimidine and pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones

Ethyl 5-amino-3-trifluoromethyl-1H-pyrazole-4-carboxylate (1) was efficiently synthesized via the condensation of ethyl cyanoacetate and trifluoroacetic anhydride, followed by chloridization and the condensation with aqueous hydrazine. Its unique reactivi

DERIVATIVES OF SUBSTITUTED VINYLPHOSPHONIC ACID

By the reactions of activated chloroalkylenes - 2,2,2-trifluoro-1-chloroethylidenemalononitrile, alkyl-4,4,4-trifluoro-3-chloro-2-cyano-2-butanoates, and dialkyl-3,3,3-trifluoro-2-chloro-1-cyano-1-propenyl phosphonates with trialkyl-, dialkylchloro-, and dialkylphosphites the corresponding products of the chlorine atom substitution for dialkoxyphosphoryl, alkoxychloro- and alkoxyfluorophosphoryl groups were obtained.During the condensation of dialkylcyanomethylphosphonate with trifluoroacetic acid ester in the presence of sodium alkoxide in alcohol followed by the action of phosphorus pentachloride, alkyl-3,3,3-trifluoro-2-chloro-1-cyano-1-propenyl phosphonates and dialkyl-3,3,3-trifluoro-2-chloro-1-cyano-1-propenyl phosphonates were synthesized.

SYNTHESIS AND TRANSFORMATIONS OF 1-CYANO-2-CHLOROETHYLENES WITH PERFLUOROALKYL AND TRIFLUOROMETHYLTHIO GROUPS

The synthesis of 1-cyano-2-chloroethylenes containing CF3, C2F5, C3F7, and SCF3 groups was realized.The products from substitution of the chlorine atoms in them by a phenylamino group are converted into derivatives of 4-aminoquinoline and 4-quinolone when