77436-49-8

Upstream product

• 864131-95-3 N,N'-diphenylformamidine 
• 135-19-3 β-naphthol 
• 62-53-3 aniline 
• 708-06-5 2-hydroxynaphthalene-1-carbaldehyde 
• 6780-49-0 ethyl N-phenylformimidate 
• 55135-70-1 (Z)-1-((phenylamino)methylene)naphthalen-2-one 
• 95093-13-3 2-hydroxy-[1]dithionaphthoic acid 
• 64-17-5 ethanol 

Downstream Products

• 872277-05-9 1-(1,2-bis-phenylimino-ethyl)-[2]naphthol 
• 6638-95-5 1-(phenylaminomethyl)naphthalen-2-ol 
• 31012-22-3 N-(2-hydroxy-1-naphthylidene)-1-butylamine 
• 62-53-3 aniline 
• 139640-68-9 (1,2-Dihydro-naphtho[2,1-b]furan-1-yl)-phenyl-amine 
• 19052-38-1 VO(2-hydroxyl-1-naphthalidene-anil)2 
• 90759-56-1 Pt(OC₁₀H₆CHNC₆H₅)2 
• 89669-40-9 (C₆H₅)3Sn(N₃)(C₁₀H₆(OH)CHNC₆H₅)2 
• 89680-57-9 (C₆H₅)3Sn(NCO)(C₁₀H₆(OH)CHNC₆H₅)2 
• 89669-39-6 (C₆H₅)3Sn(NCS)(C₁₀H₆(OH)CHNC₆H₅)2 
• 79553-12-1 bis[1-[(phenylimino)methyl]-2-naphtholato]cobalt(II) complex 
• 137940-61-5 nickel bis(2-hydroxy-1-naphthylidene aniline) 
• 79632-72-7 (Co(C₁₀H₆(O)CHNC₆H₅)2(H₂O)2) 

Relevant academic research and scientific papers

Triarylborane-Appended Anils and Boranils: Solid-State Emission, Mechanofluorochromism, and Phosphorescence

Herein, the design, synthesis, optical properties, and mechanofluorochromism characteristics of a series of conjugates having covalently linked triarylborane (TAB) and anil/boranil units (TAB-anil: 1 a–3 a and TAB-boranil: 1–3) are reported. The electronic interactions between TAB and anil/boranil in 1 a–3 a and 1–3 were fine-tuned by changing the boryl moiety's position on the phenyl spacer connecting the BMes2 (Mes=mesityl) and anil/boranil units. A boryl moiety at the meta position (1 a) of the phenyl spacer stabilizes the enolic form (E-OH), whereas a boryl moiety at the para position (2 a and 3 a) stabilizes the keto form (Z-NH) in the solid state. However, in solution 1 a, 2 a, and 3 a exhibit keto–enol tautomerism in both ground and excited states. Compounds 1 a–3 a and 1–3 show red-shifted absorption compared with 4 a and 4, which are devoid of TAB moieties, which indicate effective participation of an empty p orbital on the boron center in 1 a–3 a and 1–3. Compounds 1 and 2 showed fluorescence variations in response to external stimuli such as mechanical grinding. Long phosphorescence lifetimes of 18–46 ms were observed for compounds 1–3. The observed optical properties of 1 a–3 a and 1–3 are rationalized in the context of quantum mechanical calculations.

1-[(2-Hydroxy-phenylimino)-methyl]-naphthalen-2-ol: application in detection and adsorption of aluminum ions

A novel “on–off” Al3+ ions fluorescence-enhanced sensor (E)-1-(((2-hydroxyphenyl) imino)methyl)naphthalen-2-ol (AH-2) and its hydrogel hybrid (PAMN) were synthesized. AH-2 showed excellent selectivity and ultrasensitive to Al3+ ions;

7-OH quinoline Schiff bases: are they the long awaited tautomeric bistable switches?

Two novel, 7-hydroxyquinoline based, Schiff bases have been synthesized and their spectral properties have been investigated by combined use of optical and NMR spectroscopy and theoretical DFT calculations. The results indicate that 8-((phenylimino)methyl)quinolin-7-ol exists as a mixture of enol and two keto tautomers in solution, while 8-(((pentarfluorophenyl)imino)methyl)quinolin-7-ol is presented as a single enol form. Upon irradiation, in both compounds, through excited state intramolecular proton transfer mechanism, a rotation around the Cquin-CH bond occurs, indicating that they are suitable to be used as bistable switches. The back relaxation is faster comparing to the theoretical expectations, due to the additional flexibility around the azomethine bond. As a result of forming complexes with the acidic counter ion, no intramolecular rotation happens upon protonation with trifluoroacetic acid.

Half-Sandwich Iridium Complexes for the One-Pot Synthesis of Amides: Preparation, Structure, and Diverse Catalytic Activity

Several types of air-stable N,O-coordinate half-sandwich iridium complexes containing Schiff base ligands with the general formula [Cp*IrClL] were synthesized in good yields. These stable iridium complexes displayed a good catalytic efficiency in amide synthesis. A variety of amides with different substituents were obtained in a one-pot procedure with excellent yields and high selectivities through the amidation of aldehydes with NH2OHHCl and nitrile hydration under the catalysis of complexes 1-4. The excellent and diverse catalytic activity, mild conditions, broad substance scope, and environmentally friendly solvent make this system potentially applicable in industrial production. Half-sandwich iridium complexes 1-4 were characterized by NMR, elemental analysis, and IR techniques. Molecular structures of complexes 2 and 3 were confirmed by single-crystal X-ray analysis.

YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4

Binding of the transcriptional co-activator, YAP1, to the transcription factor Oct4, induces Sox2, which is a transcription actor necessary for the self-renewal of stem-like cells from non-small cell lung cancer. The WW domain of YAP1 binds to the PPxY motif of Oct4 to induce Sox2. Delivering a peptide corresponding to the WW domain could prevent the induction of Sox2 and stemness. Similarly, peptides and mimetics of the PPxY motif would be able to inhibit stemness. Disclosed are compounds that affect the Yap1:Oct4 interaction.

N,O-coordinated bivalent nickel complex with binaphthol structure and preparation method thereof

The invention provides N,O-coordinated bivalent nickel complex with binaphthol structure, having a structural formula shown in the description; the invention also provides a preparation method of the N,O-coordinated bivalent nickel complex with binaphthol

Cyclometalated Pt(ii) complexes with a bidentate Schiff-base ligand displaying unexpected: Cis / trans isomerism: Synthesis, structures and electronic properties

Square planar platinum complexes are an important class of compounds used in (nano)technology, optoelectronics, medicinal chemistry and catalysis. The major research interests in cyclometalated Pt(ii) complexes focus on the selective modulation of their electronic properties and the control of the (cis/trans) geometry. For the first time, we unveil and demonstrate that cis-trans isomers of Pt(ii) complexes can be obtained in a derivative carrying the 1-phenyl-pirazolate (Hppz) and 2-hydroxy-1-naphtyl-(N-phenyl)imine ligands. The two isomers display significant differences in both optical and electronic properties. While luminescence is quenched in solution, they are brightly emissive in the PMMA matrix at room temperature and in the 2MeTHF rigid matrix at 77 K. The phosphorescent emission of the cis isomer, blue-shifted compared to that of the trans one, results from the significantly different trans influence of the ppz ligand. Theoretical investigation highlights the almost isoenergetic potential energy of the two isomers therefore explaining their formation and evidences a large geometry distortion of their triplet state, which should be responsible for the observed luminescence efficiency.

Syntheses, characterization and catalytic activities of half-sandwich ruthenium complexes with naphthalene-based Schiff base ligands

Four ruthenium(II) p-cymene complexes with naphthalene-based Schiff base ligands [Ru(p-cymene)LCl] (2a–2d) have been synthesized and characterized. The half-sandwich ruthenium complexes were characterized by 1H and 13C NMR spectra, elemental analyses, and infrared spectrometry. The molecular structures of 2a, 2b, and 2c were confirmed by single-crystal X-ray diffraction. Furthermore, these half-sandwich ruthenium complexes are highly active catalysts for the hydrogenation of nitroarenes to anilines using NaBH4 as the reducing agent in ethanol at room temperature.

Synthesis of a series of new platinum organometallic complexes derived from bidentate Schiff-base ligands and their catalytic activity in the hydrosilylation and dehydrosilylation of styrene

The synthesis and properties of a novel class of platinum complexes containing Schiff bases as O,N-bidentate ligands is described as are the solution and solid state properties of the uncomplexed ligands. The platinum complexes were prepared from [PtBr2(COD)] (COD = 1,5-cyclooctadiene) and N-(2-hydroxy-1-naphthalidene)aniline derivatives in the presence of base (NaOBut). Instead of a substitution reaction to afford cationic species, the addition of the Schiff base ligands results in both the formal loss of two equivalents of bromide and addition of hydroxide to the COD ligand of the complexes. It is proposed that this reaction proceeds through a cationic platinum complex [Pt(N-O)(COD)]Br which then undergoes addition of water and loss of HBr. An example of a dinuclear platinum complex in which two cyclo-octene ligands are bridged by an ether linkage is also reported. The platinum complexes were evaluated as catalysts for the hydrogenative and dehydrogenative silylation of styrene, the resulting behaviour is substituent, time and temperature dependent.

Synthesis, spectroscopic characterization, catalytic and antibacterial studies of ruthenium(III) Schiff base complexes

The bidentate Schiff base ligands (HLn) have been synthesized by condensation of 2-hydroxy-l-naphthaldehyde with aniline and its p-substituted derivatives in ethanol. Ruthenium(III) complexes of the type [Ru(Ln)2(H2O)2]Cl have been synthesized by the reaction of RuCl3·nH2O with the Schiff base ligands (in a molar ratio 1:2) in ethanol. The ligands and their Ru(III) complexes have been characterized by elemental analysis, magnetic susceptibility, spectroscopic (FTIR, UV-vis, 1H NMR and X-ray diffraction) and thermal analysis techniques. All the ruthenium(III) complexes are found to be stable, paramagnetic, low spin and octahedrally coordinated by the ligands through the nitrogen atom of the azomethine (-CN-) group and the oxygen atom of the deprotonated phenolic group. The molecular and electronic structures of the investigated ligands (HLn) were also studied using quantum chemical calculations. The complexes (1, 3 and 5) exhibited a catalytic activity for the oxidation of benzoin to benzil with moderate to high yield in the presence of sodium periodate as co-oxidant. The antibacterial activities of the ligands (HLn) and their Ru(III) complexes towards Gram positive and Gram negative bacteria have been investigated.