774490-79-8Relevant academic research and scientific papers
Regioselective copper(II)-mediated bromoamination of unfunctionalized olefins: An efficient route to N-heterocyclic compounds
Liu, Gong-Qing,Ding, Zhen-Ying,Zhang, Li,Li, Ting-Ting,Li, Lin,Duan, Lili,Li, Yue-Ming
, p. 2303 - 2310 (2014/07/21)
Bromoamination of unfunctionalized olefins was realized under mild conditions using copper(II) bromide (CuBr2) as both reaction promoter and bromine source. The reactions could be carried out under open air at ambient temperature, and both N-alkylated and N-tosylated substrates could be converted to the corresponding N-heterocyclic compounds in high regioselectivity and good isolated yields. A variety of biologically important structures could be obtained via subsequent nucleophilic substitution reactions.
Transition metal-free iodine-promoted haloamination of unfunctionalized olefins
Li, Wei,Liu, Gong-Qing,Cui, Bin,Zhang, Li,Li, Ting-Ting,Li, Lin,Duan, Lili,Li, Yue-Ming
, p. 13509 - 13513 (2014/04/03)
A transition metal-free route to 3-halopiperidines and 2- halomethylpiperidines was described. In the presence of iodine, potassium persulfate and a suitable halogen source, intramolecular haloamination of 4-penten-1-amines and 5-hexen-1-amines proceeded readily, leading to the corresponding substituted piperidines in good isolated yields. This journal is the Partner Organisations 2014.
Synthesis and reaction of 1-azabicyclo[3.1.0]hexane
Hayashi, Kazuhiko,Kujime, Eiko,Katayama, Hajime,Sano, Shigeki,Shiro, Motoo,Nagao, Yoshimitsu
experimental part, p. 1142 - 1146 (2010/03/31)
The effective formation of 1-azabicyclo[3.1.0]hexane (5) by treatment of 2-(bromomethyl)pyrrolidine hydrobromide (4) with n-BuLi was established, with the reaction occurring by a rational reaction pathway via the open chain transition state 8 based on int
