77451-93-5Relevant academic research and scientific papers
Fischer Indole Synthesis of 3-Acyl and 3-Alkoxy-carbonylindoles
Mills, Keith,Khawaja, Ibtisam K. Al,Al-Saleh, Fowzia,Joule, John A.
, p. 636 - 641 (2007/10/02)
N-Benzyl-N-phenylhydrazine derivatives of 1,3-diketones and 1,3-ketoesters undergo normal Fischer cyclisations to indoles, but no method could be found for the subsequent removal of the N-protecting group.No method could be found for the indolisation of N-aroyl-N-phenylhydrazine derivatives of dimedone with retention of the N-protecting group, though heating in tetralin did effect the electrocyclic step of the Fischer sequence and the formation of a carbon-carbon bond.
