774536-58-2

Upstream product

• 628734-09-8 (+/-)-N-{3-[[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-propyl]-(4-methyl-benzoyl)-amino]-propyl}-carbamic acid tert-butyl ester 
• 749206-48-2 1-amino-5-chloro-1H-pyrrole-2-carboxylic acid methyl ester 
• 628734-14-5 7-chloro-2-methyl-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one 
• 628734-15-6 3-benzyl-7-chloro-2-methyl-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one 
• 628734-17-8 3-benzyl-7-chloro-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazine-2-carbaldehyde 
• 628734-16-7 3-benzyl-7-chloro-2-(2-dimethylamino-vinyl)-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one 
• 628734-08-7 (+/-)-N-{3-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-pyrrolo [2,1-f][1,2,4]triazin-2-yl)-propylamino]-propyl}-carbamic acid tert-butyl ester 
• 1757-31-9 methyl 5-chloro-1H-pyrrole-2-carboxylate 

Relevant academic research and scientific papers

Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors

Synthesis and SAR of substituted pyrrolotriazine-4-one analogues as Eg5 inhibitors are described. Many of these analogues displayed potent inhibitory activities in the Eg5 ATPase and A2780 cell proliferation assays. In addition, pyrrolotriazine-4-one anal