77456-95-2

Upstream product

• 3417-91-2 L-tyrosine methyl ester HCl 
• 25518-33-6 methyl (tert-butoxycarbonyl)-L-valyl-L-tyrosinate 
• 75957-53-8 N-[N-(tert-butoxycarbonyl)-L-valyl]-L-tyrosine benzyl ester 
• 3392-17-4 Boc-Val-Tyr-OEt 
• 949-67-7 L-tyrosine ethyl ester 

Downstream Products

• 78819-64-4 N^α-tert-butoxycarbonylvalyltyrosylproline benzyl ester 
• 187806-92-4 (S)-2-{[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-3-methyl-butyryl]-methyl-amino}-3-(4-methoxy-phenyl)-propionic acid 
• 1098101-21-3 tert-butyloxycarbonyl-valyl-tyrosyl-phenylalanyl-glycine methyl ester 
• 78819-67-7 valyltyrosylproline benzyl ester 
• 78819-69-9 N^α-tert-butoxycarbonylvalyl-N^ε-benzyloxycarbonyllysylvalyltyrosylproline benzyl ester 
• 78819-70-2 HValLys(Z)ValTyrProOBzl 
• 187806-98-0 (S)-2-({(S)-2-[(2-{(S)-2-[(2-tert-Butoxycarbonylamino-acetyl)-methyl-amino]-4-methyl-pentanoylamino}-acetyl)-methyl-amino]-3-methyl-butyryl}-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid benzyl ester 

Relevant academic research and scientific papers

Direct modification of tripeptides using photoinduced decarboxylative radical reactions

In order to explore the applicability of photoinduced electron transfer (PET) promoted decarboxylative reactions to the direct modification of peptides, a study was performed to assess the influence of amino acid side chains on photoreactions of N-terminal protected tripeptides. Photoinduced decarboxylation reactions of tripeptides, which are composed of central amino acids that possess alkyl, phenyl, thioether, hydroxy, and amide containing side chains, in the presence or absence of acrylonitrile and a thiol were found to proceed smoothly to give the corresponding radical addition, H-abstraction, and substitution products. Although photoreactions of tripeptides containing central amino acids with phenol and indole (Tyr and Trp) moieties do not take place efficiently, appropriate protection of these groups enables the substrates to undergo smooth photoinduced decarboxylative reactions.

PEPTIDE DERIVATIVES AND ANGIOTENSIN IV RECEPTOR AGONIST

Short-chain peptide derivatives acting on angiotensin IV receptor at low concentrations. Because of agonistically acting on angiotensin IV receptor, the novel peptide derivatives of the present invention represented by the following formula (1) are useful as remedies for various diseases in which angiotensin IV participates:

Dolastatins. 26. Synthesis and stereochemistry of dolastatin 11

The first synthesis of dolastatin 11, a potent antineoplastic agent from the sea hare Dolabella auricularia, confirmed the proposed structure and established the last configuration in this natural product and in dolastatin 12, majusculamide C, and 57-norm