774567-83-8Relevant articles and documents
Palladium-Catalyzed Ring-Forming Aminoalkenylation of Alkenes with Aldehydes Initiated by Intramolecular Aminopalladation
Hu, Yue,Xie, Yinjun,Shen, Zhiqiang,Huang, Hanmin
, p. 2473 - 2477 (2017)
A palladium-catalyzed aminopalladation reaction followed by nucleophilic addition with aldehydes and dehydration is described. This direct and operationally simple procedure provides a rapid and reliable approach to a wide range of functionalized tetrahydroisoquinolines with high selectivity. Mechanistic studies disclosed that the nucleophilic addition, performed via a highly ordered transition-state, is the turnover-limiting step in which the inherent β-hydride elimination of the key Csp3?Pd species was controlled by the confined conformation and the nucleophilicity of the Csp3?Pd bond was enhanced by the strong electron-donating effect of the nitrogen atom.
1,7-electrocyclization reactions of 2-Aza-4,5-benzoheptatrienyl- and 4-Aza-6,7-benzononatetraenyllithium compounds: Synthesis of novel 2-benzazepines and (benzocyclooctenyl) amines
Sajitz, Melanie,Froehlich, Roland,Wurthwein, Ernst-Ulrich
experimental part, p. 2342 - 2353 (2009/09/05)
Deprotonation reactions of N-benzyl- and N-allylimines 1 and 4 led to benzo-annulated 2-azaheptatrienyl- and 4- azanonatetraenyllithium compounds, which underwent 1,7- electrocyclization reactions to yield the novel 2,3-dihydro- 1/f-benzo[c]azepines 3, 5,
