774567-83-8Relevant academic research and scientific papers
Palladium-Catalyzed Ring-Forming Aminoalkenylation of Alkenes with Aldehydes Initiated by Intramolecular Aminopalladation
Hu, Yue,Xie, Yinjun,Shen, Zhiqiang,Huang, Hanmin
, p. 2473 - 2477 (2017)
A palladium-catalyzed aminopalladation reaction followed by nucleophilic addition with aldehydes and dehydration is described. This direct and operationally simple procedure provides a rapid and reliable approach to a wide range of functionalized tetrahydroisoquinolines with high selectivity. Mechanistic studies disclosed that the nucleophilic addition, performed via a highly ordered transition-state, is the turnover-limiting step in which the inherent β-hydride elimination of the key Csp3?Pd species was controlled by the confined conformation and the nucleophilicity of the Csp3?Pd bond was enhanced by the strong electron-donating effect of the nitrogen atom.
Phosphazene base-catalyzed hydroamination of aminoalkenes for the construction of isoindoline scaffolds: Application to the total synthesis of aristocularine
Matsuoka, Junpei,Terashita, Maki,Miyawaki, Akari,Tomioka, Kiyoshi,Yamamoto, Yasutomo
, (2021/12/30)
A method for isoindoline synthesis via phosphazene base-catalyzed intramolecular hydroamination of aminoalkenes was developed. The reaction has a broad functional group tolerance, including for halide, cyano, and methoxy groups, and could also be used to
1,7-electrocyclization reactions of 2-Aza-4,5-benzoheptatrienyl- and 4-Aza-6,7-benzononatetraenyllithium compounds: Synthesis of novel 2-benzazepines and (benzocyclooctenyl) amines
Sajitz, Melanie,Froehlich, Roland,Wurthwein, Ernst-Ulrich
experimental part, p. 2342 - 2353 (2009/09/05)
Deprotonation reactions of N-benzyl- and N-allylimines 1 and 4 led to benzo-annulated 2-azaheptatrienyl- and 4- azanonatetraenyllithium compounds, which underwent 1,7- electrocyclization reactions to yield the novel 2,3-dihydro- 1/f-benzo[c]azepines 3, 5,
