77458-01-6 Usage
Uses
Pyraclofos is used to control Lepidoptera, Coleoptera, mites and
nematodes in fruit, vegetables, ornamentals and forestry. It has also been
used in a human health application to control filarial worms.
Metabolic pathway
Pyraclofos is apparently subjected in insects to a metabolic activation to
yield a more active acetylcholinesterase inhibitor which is possibly a
thiooxidized metabolite. The compound is very rapidly degraded in
mammals to inactive metabolites via P-O-aryl, P-O-alkyl and P-S-alkyl
cleavage which explains its favourable selective toxicity. In both mammals
and plants the principal degradative route is via P-O-aryl cleavage to
give 1-(4-chlorophenyl)-4-hydroxypyrazolwe hich is rapidly conjugated.
Metabolism
Pyraclofos
is metabolized to an active AChE inhibitor, probably by
the oxidation of the sulfur atom in the phosphorothiolate
linkage. The half-life in soil is 3–38 d, depending on
soil type.
Toxicity evaluation
The acute oral LD50 for
rats is 237 mg/kg. The inhalation LC50 for rats is
1.69 mg/L air. NOEL (2 yr) for rats is 0.10–0.12 mg/kg
diet (0.005–0.006 mg/kg/d). Pyraclofos administered to
rats is rapidly degraded, and more than 90% of the
dose is excreted principally in the urine within 24 h. The
degradation routes are cleavages of the P?S, P?O-alkyl,
and P?O-aryl bonds in both animals and plants.
Degradation
The DT50 for hydrolysis in water at pH 7 (25 °C) was 29 days (PM).
Check Digit Verification of cas no
The CAS Registry Mumber 77458-01-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,4,5 and 8 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 77458-01:
(7*7)+(6*7)+(5*4)+(4*5)+(3*8)+(2*0)+(1*1)=156
156 % 10 = 6
So 77458-01-6 is a valid CAS Registry Number.
InChI:InChI=1/C14H18ClN2O3PS/c1-3-9-22-21(18,19-4-2)20-14-10-16-17(11-14)13-7-5-12(15)6-8-13/h5-8,10-11H,3-4,9H2,1-2H3
77458-01-6Relevant articles and documents
Pyrazol-4-yl phosphites
-
, (2008/06/13)
A 4-pyrazolyl phosphorous acid ester of the following formula, STR1 (R is a lower alkyl group; Y is a phenyl group which may optionally be substituted by a halogen, halogens, a lower alkyl group or a halogen and a lower alkyl group.) which is produced by reacting corresponding 4-hydroxylpyrazole compound with a trialkyl phosphite. The ester gives 4-pyrazolyl phosphorothioate by the reaction with an alkylsulfenyl halide.
