7746-65-8

Upstream product

• 100-44-7 benzyl chloride 
• 35572-84-0 4-phenyl-1-phenylcarbamoyl thiosemicarbazide 
• 103-72-0 phenyl isothiocyanate 
• 103557-05-7 2-(anilinothioformyl)hydrazine-1-carboxylic acid methyl ester 
• 27106-12-3 2-hydroxy-5-mercapto-1-phenyl-1,3,4-triazole 
• 5351-69-9 4-Phenyl-3-thiosemicarbazide 
• 27106-12-3 4-phenyl-5-sulfanyl-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 134832-68-1 C₈H₈N₃OS₂^(1-)*Na⁽¹⁺⁾ 
• 103-71-9 phenyl isocyanate 
• 121941-97-7 5-Phenylamino-[1,3,4]oxadiazole-2-thiol 
• 134832-81-8 C₁₅H₁₅N₃OS₂ 
• 134832-73-8 (5-Benzylsulfanyl-[1,3,4]oxadiazol-2-yl)-phenyl-amine 

Relevant academic research and scientific papers

Synthesis and evaluation of the anticonvulsant activity of 5-alkylthio-4-phenyl-2,4-dihydro-3H-1,2,4-triazol-3-one derivatives

A new series of 5-alkylthio-4-phenyl-2,4-dihydro-3H-1,2,4-triazol-3-one derivatives (4a-w) have been synthesized and tested for their anticonvulsant activity using the maximal electroshock (MES) test. The results indicated that all of the target compounds

Synthesis of substituted-δ2-1,2,4-triazolin-5-ones and S-substituted isothiobiureas from 1-aryl/alkyl-6-phenyl-2-thiobiureas

Reaction of 1-aryl/alkyl-6-phenyl-2-thiobiureas 1 with BnCl and BuI in neutral medium at reflux temperature resulted in the formation of the S-alkylated isothiobiureas 2 and 1,2,4-triazolin-5-one derivatives 3. A convenient route to 2 is also reported.

Carbon oxysulphide: A novel reagent for the synthesis of 4-amino/anilino-3-aryl/aryloxymethyl/thiophenoxymethyl-1,2,4-triazolin-5-ones and 5-arylamino-2-mercapto-1,3,4-oxadiazoles

Acid hydrazides 1 on reaction with carbon oxysulphide in the presence of alcoholic KOH afford potassium β-acylthiocarbazinates 2 which on further reaction with hydrazine hydrate or phenylhydrazine give 4-amino-3-substituted-1,2,4-triazolin-5-ones 3 and 4-amilino-3-substituted-1,2,4-triazolin-5-ones 5 respectively. 4-Substituted thiosemicarbazides 6 on treatment with carbon oxysulphide in the presence of ale NaOH afford sodium β-(N-arylthiocarbamyl)thiocarbazinates 7 which on cyclisation in the presence of ethanolic NaOH afford 5-arylamino-2-mercapto-1,3,4-oxadiazoles 8. On reaction with benzyl chloride in the presence of NaOH 8 isomerise to 3-benzylmercapto-4-substituted-1,2,4-triazolin-5-ones 9.

Thiocarbazinic acids: Interaction of carbonoxysulphide with thiosemicarbazides - Synthesis of &β-(thiocarbamyl)thiocarbazinates and 1,3,4-oxadiazole and 1,2,4-triazole derivatives

Interaction of carbon oxysulphide with 4-alkyl/arylthiosemicarbazides (I) in ethanol in the presence of sodium hydroxide forms sodium β-(N-alkyl/arylthiocarbamyl)thiocarbazinates (II).Benzylation of the latter (II) affords 5-alkyl/arylamino-2-benzylmercapto-1,3,4-oxadiazoles (IV), which can also be obtained by a one-pot synthesis involving the reaction of I with carbon oxysulphide in DMF in the presence of triethylamine and benzyl chloride.The syntheses of benzyl β-(N-alkyl/arylthiocarbamyl)thiocarbazinates (III) and 4-aryl-3-mercapto-1,2,4-triazolin-5-ones (VII) are also reported.Some of the compounds exhibit antibacterial activity.