774607-89-5

Upstream product

• 774607-88-4 2-(5-chloro-2-methoxy-phenyl)-pyrimidine-4,6-diol 
• 55877-79-7 2-methoxy-5-chlorobenzonitrile 

Downstream Products

• 774607-90-8 hydrochloride salt of 6-chloro-2-(5-chloro-2-methoxy-phenyl)-pyrimidin-4-yl-amine 
• 794494-75-0 6-chloro-2-(5-chloro-2-methoxy-phenyl)-pyrimidin-4-ylamine 

Relevant academic research and scientific papers

Pyrimidines and uses thereof

The invention relates to pyrimidines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity and/or proliferation of cells such as tumor-cells.

Synthesis, SAR, and antitumor properties of diamino-C,N-diarylpyrimidine positional isomers: Inhibitors of lysophosphatidic acid acyltransferase-β

2,4-Diamino-N4,6-diarylpyrimidines were identified as potent, isoform specific inhibitors of lysophosphatidic acid acyltransferase-β (LPAAT-β). Active inhibitors also blocked proliferation of tumor cell lines in vitro. The effect of 2j in an in