774608-08-1Relevant academic research and scientific papers
Synthesis, SAR, and antitumor properties of diamino-C,N-diarylpyrimidine positional isomers: Inhibitors of lysophosphatidic acid acyltransferase-β
Gong, Baoqing,Hong, Feng,Kohm, Cory,Jenkins, Scott,Tulinsky, John,Bhatt, Rama,De Vries, Peter,Singer, Jack W.,Klein, Peter
, p. 2303 - 2308 (2007/10/03)
2,4-Diamino-N4,6-diarylpyrimidines were identified as potent, isoform specific inhibitors of lysophosphatidic acid acyltransferase-β (LPAAT-β). Active inhibitors also blocked proliferation of tumor cell lines in vitro. The effect of 2j in an in
Pyrimidines and uses thereof
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, (2008/06/13)
The invention relates to pyrimidines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity and/or proliferation of cells such as tumor-cells.
