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4-Methyl-6-ethoxypyrimidine-2-amine is a chemical compound with the formula C8H12N4O, featuring a pyrimidine ring with a methyl group at the 4-position and an ethoxy group at the 6-position. It is also known as the intermediate 5 of Riociguat in the synthesis of the soluble guanylate cyclase stimulator.
Used in Pharmaceutical Industry:
4-Methyl-6-ethoxypyrimidine-2-amine is used as a reagent and intermediate for the synthesis of various drugs and active ingredients, particularly those targeting the cardiovascular and pulmonary systems. It plays a crucial role in the development of therapeutic agents for conditions such as pulmonary hypertension and chronic thromboembolic pulmonary hypertension.

7749-48-6

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7749-48-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 7749-48-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,7,4 and 9 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 7749-48:
(6*7)+(5*7)+(4*4)+(3*9)+(2*4)+(1*8)=136
136 % 10 = 6
So 7749-48-6 is a valid CAS Registry Number.
InChI:InChI=1/C7H11N3O/c1-3-11-6-4-5(2)9-7(8)10-6/h4H,3H2,1-2H3,(H2,8,9,10)

7749-48-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-ethoxy-6-methylpyrimidin-2-amine

1.2 Other means of identification

Product number -
Other names 4-Ethoxy-6-methyl-2-pyrimidinamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:7749-48-6 SDS

7749-48-6Relevant academic research and scientific papers

Synthesis of hitherto unknown 4,4-bis(Methylthio)but-3-en-2-one-1,1,1,3- d4 and its application as 1,3-dielectrophilic building block for the synthesis of deuterated heterocycles and aromatics

Charanraj,Ramachandra,Ramesh,Junjappa

, p. 412 - 417 (2018/05/22)

Acetone-d6 has been transformed for the first time to 4,4-bis(methylthio)but-3-en-2-one- 1,1,1,3-d4. This tetradeutero-α-oxoketenedithioacetal is shown to be an excellent 1,3-dielectrophilic building block for the synthesis of 5- and

Research on heterocyclic compounds - Part XXXIX. 2-Methylimidazo[1,2-a]pyrimidine-3-carboxylic derivatives: Synthesis and antiinflammatory activity

Laneri, Sonia,Sacchi, Antonia,Gallitelli, Marina,Arena, Francesca,Luraschi, Elena,Abignente, Enrico,Filippelli, Walter,Rossi, Francesco

, p. 163 - 170 (2007/10/03)

The synthesis of a group of 2-methylimidazo[1,2-a]pyrimidine-3-carboxylic esters, acids and amides is described. The structures of new compounds are supported by 1H and 13C NMR spectra. These compounds were tested in vivo for their antiinflammatory analgesic and ulcerogenic activity. Eight new compounds out of fifteen showed remarkable dose-dependent antiinflammatory action in die carrageenan rat paw edema (1/2-1/3 x indomethacin) but weak analgesic activity in the acetic acid writhing test together with negligible ulcerogenic action. The new compounds were found to be lacking in inhibitory activity on cyclooxygenase in vitro.

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