77497-97-3

Usage

Uses

Different sources of media describe the Uses of 77497-97-3 differently. You can refer to the following data:
1. Quinapril intermediate
2. Used to prepare a novel class of antifungal agents.

InChI:InChI=1/C17H17NO2.C7H8O3S/c19-17(20-12-13-6-2-1-3-7-13)16-10-14-8-4-5-9-15(14)11-18-16;1-6-2-4-7(5-3-6)11(8,9)10/h1-9,16,18H,10-12H2;2-5H,1H3,(H,8,9,10)/t16-;/m0./s1

Upstream product

• 6192-52-5 p-toluenesulfonic acid monohydrate 
• 77497-95-1 (3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride 
• 100-51-6 benzyl alcohol 
• 63-91-2 L-phenylalanine 
• 104-15-4 toluene-4-sulfonic acid 
• 74163-81-8 L-Tic-OH 

Downstream Products

• 87022-29-5 benzyl (3S)-2-(3-benzoylthio-2-methylpropionyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 
• 77497-96-2 (S)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid, phenylmethylester 
• 134732-98-2 (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide 
• 501355-25-5 (S)-N-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide 
• 1636138-31-2 (S)-N-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide 
• 1238365-87-1 (S)-N-[(1R)-1-phenylethyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide 
• 1238365-88-2 (S)-N-[(1S)-1-phenylethyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide 
• 1636138-33-4 (S)-N-[(1R)-1-phenylethyl]-1,2,3,4-tetrahydroisoquinoline-3-thiocarboxamide 
• 1636138-35-6 (S)-N-[(1S)-1-phenylethyl]-1,2,3,4-tetrahydroisoquinoline-3-thiocarboxamide 
• 1636138-39-0 (5S)-3(4-nitrophenyl)-2-[(1R)-(1-phenylethyl)]-2,3,10,10a-tetrahydro-5H-imidazo[1,5-b]isoquinoline-1-thione 
• 673461-28-4 (S)-N-phenyl-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide 
• 1636138-41-4 (5S)-3,3-dimethyl-2-[(1R)-(1-phenylethyl)]-2,3,10,10a-tetrahydro-5H-imidazo[1,5-b]isoquinoline-1-thione 
• 115962-35-1 (3S)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinole-3-carboxylic acid 
• 673461-23-9 (S)-N-benzyl-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide 

Relevant academic research and scientific papers

Synthesis and characterization of n-substituted (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxamides and thioamides as organocatalysts for asymmetric aldol reaction

In this paper, the preparation and characterization of eight optically pure N-functionalized (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxamides and thioamides is described. The prepared amides and thioamides were tested as organocatalysts of aldol reaction of 4-nitrobenzaldehyde and acetone. The highest ee of formation of 4-hydroxy-4-(4-nitrophenyl)butan-2-one was obtained with (S)-N-[(1R)-1-phenylethyl]-1,2,3,4-tetrahydroisoquinoline-3-thiocarboxamide (77% ee). The observed deceleration of the aldol reaction catalyzed in this way, as compared with that catalyzed with (S)-proline, was attributed to the formation of little reactive cyclic intermediate, which was isolated and characterized.

Synthesis and biological activities of a novel class of azole-containing antifungal agents

A series of novel 1,2,3,4-tetrahydroisoquinoline derived azoles has been designed and synthesized as antifungal agents which might function as inhibitors of cytochrome P-450 dependent lanosterol 14α-demethylase. In vitro tests showed that some of these compounds, especially 5b and 6b, effectively inhibit the growth of several strains of yeasts as well as molds.