775-66-6Relevant academic research and scientific papers
Unusual self-assembly of a hydrophilic β-cyclodextrin inclusion complex into vesicles capable of drug encapsulation and release
Nayak, Nagaraj,Gopidas, Karical R.
, p. 3425 - 3428 (2015)
Formation of a hydrophilic β-cyclodextrin bis-inclusion complex and its self-assembly into supramolecular vesicles are described. The vesicles can be loaded with the anti-cancer drug doxorubicin and the loaded drug can be released upon addition of a competitive inclusion binder such as adamantane carboxylate.
Tubuloclustin analogues with ether moiety: synthesis and evaluation of tubulin clustering and antimitotic activity in cancer cells
Zefirov, Nikolay A.,Gadert, Leonie,Fatkulin, Artemy R.,Shibilev, Vadim M.,Butov, Gennady M.,Mokhov, Vladimir M.,Kuznetsov, Sergei A.,Zefirova, Olga N.
, p. 106 - 108 (2020)
New analogues of anticancer agent tubuloclustin N-[7-(adamantan-1-yloxy)-7-heptanoyl]-N-deacetylcolchicine with ether moiety in the linker between colchicine and adamantine fragments were synthesized from w-(adamantan-1-yloxy)alkan- 1-ols. These compounds effectively inhibited growth of human lung carcinoma cell line A549 (IC50 = 5–15.5 nM), induced both apoptosis and formation of tubulin clusters. The conjugates lacking ester carbonyl in the linker exhibit improved metabolic stability and are promising for further cytotoxicity studies in vivo.
A Newly Designed Water Soluble Uranyl-Salophen Complex for Anion Recognition
Dalla Cort, Antonella,Fantoni, Alessia,Forte, Gianpiero,Maglione, Maria S.,Tulli, Ludovico G.
, p. 848 - 851 (2021/08/30)
A novel water-soluble uranyl-salophen (salophen=N,N‘-disalicylidene-o-phenylenediaminate) complex was obtained. Solubility was achieved in aqueous methyl-β-cyclodextrin solutions, taking advantage of the host-guest interactions established with the adaman
Induction of Apoptosis in Cancer Cells by Glutathione Transferase Inhibitor Mediated Hydrophobic Tagging Molecules
Li, Xiaona,Lü, Zirui,Wang, Cong,Li, Kebin,Xu, Fengrong,Xu, Ping,Niu, Yan
supporting information, p. 720 - 725 (2021/05/31)
The abnormally high expression of glutathione transferases is closely associated with cancer incidence and drug resistance. By introducing a hydrophobic moiety to the inhibitor structure, we organized a series of degraders of glutathione transferases and
Chemical Transformations of Tetracyclo[3.3.1.13,7.01,3]decane (1,3-Dehydroadamantane): VII. Reaction of 1,3-Dehydroadamantane with Alkanediols and Amino Alcohols
Butov,Mokhov
, p. 1760 - 1763 (2019/03/26)
The reaction of 1,3-dehydroadamantane with C2–C6 α,ω-alkanediols selectively afforded ω-(adamantan- 1-yloxy)alkan-1-ols in 87–94% yield. The reaction of 1,3-dehydroadamantane with ω-aminoalkan-1- ols (2-aminoethanol and 3-aminopropan-1-ol) gave mixtures of addition products through the oxygen and nitrogen atoms, which can be readily separated by fractional vacuum distillation or crystallization.
TRIPARTITE ANDROGEN RECEPTOR ELIMINATORS, METHODS AND USES THEREOF
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Paragraph 141; 142, (2018/11/26)
The present specification discloses tripartite androgen receptor eliminators (AREs), pharmaceutical compositions and medicaments comprising such AREs, methods and uses for such AREs and compositions and medicaments, and methods and uses for AREs and compositions and medicaments for treating an androgen receptor signaling-mediated condition, disease or disorder.
