77526-86-4

Upstream product

• 13504-37-5 diethyl phenylacetylphosphonate 
• 103-80-0 phenylacetyl chloride 
• 122-52-1 triethyl phosphite 
• 103-82-2 phenylacetic acid 

Downstream Products

• 154109-12-3 (1-Hydroxyamino-2-phenyl-ethyl)-phosphonic acid diethyl ester 
• 77526-74-0 (1-Amino-2-phenyl-ethyl)-phosphonic acid diethyl ester; compound with oxalic acid 
• 77526-73-9 (1-Amino-2-phenylethyl)phosphonsaeure-diethylester 
• 118867-00-8 (R)-(1-Amino-2-phenylethyl)phosphonsaeure-diethylester 
• 1360573-99-4 diethyl{(S)-1-[(benzyloxycarbonyl)amino]-2-phenylethyl}phosphonate 
• 107072-80-0 diethyl 1?(N?benzyloxycarbonylamino)?2?phenylethylphosphonate 
• 6324-00-1 1-amino-2-phenylethanephosphonic acid 

Relevant academic research and scientific papers

Phosphonic acid analogs of fluorophenylalanines as inhibitors of human and porcine aminopeptidases N: Validation of the importance of the substitution of the aromatic ring

A library of phosphonic acid analogs of phenylalanine substituted with fluorine, chlorine and trifluoromethyl moieties on the aromatic ring was synthesized and evaluated for inhibitory activity against human (hAPN) and porcine (pAPN) aminopeptidases. Fluorogenic screening indicated that these analogs are micromolar or submicromolar inhibitors, both enzymes being more active against hAPN. In order to better understand the mode of the action of the most active compounds, molecular modeling was used. It confirmed that aminophosphonic portion of the enzyme is bound nearly identically in the case of all the studied compounds, whereas the difference in activity results from the placement of aromatic side chain of an inhibitor. Interestingly, both enantiomers of the individual compounds are usually bound quite similarly.

First Synthesis of (R)- and (S)-1,2,3,4-Tetrahydroisoquinoline-3-phosphonic Acid (TicP) Using a Pictet-Spengler Reaction

We report here a practical and efficient synthesis of diethyl 1,2,3,4-tetrahydroisoquinoline-3-phosphonate derivatives. The target compounds were prepared in good yield using a Pictet-Spengler reaction involving α-amino phosphonates that were easily obtai

Enantioselective synthesis of quaternary α-aminophosphonates via conjugate addition of α-nitrophosphonates to enones

Enantioselective Michael addition of α-nitrophosphonates to enones for the synthesis of α-aminophosphonates is reported for the first time. The reaction proceeds in good to high yields and moderate to high selectivity in the presence of a new quinine thio

Studies on organophosphorus compounds; LXXV: A facile synthesis of 1-(hydroxyamino)alkyl(or aryl)phosphonic acids

Reduction of dialkyl 1-(hydroxyimino)alkyl(aryl)phosphonate 1 with borane-pyridine complex proceeds smoothly to give dialkyl 1-(hydroxyamino)alkyl(or aryl)phosphonate 2 which is then easily converted into the corresponding hydroxyaminophosphonic acid 3 by