1360573-99-4Relevant academic research and scientific papers
First Synthesis of (R)- and (S)-1,2,3,4-Tetrahydroisoquinoline-3-phosphonic Acid (TicP) Using a Pictet-Spengler Reaction
Viveros-Ceballos, José Luis,Ordó?ez, Mario,Sayago, Francisco J.,Jiménez, Ana I.,Cativiela, Carlos
, p. 2711 - 2719 (2016)
We report here a practical and efficient synthesis of diethyl 1,2,3,4-tetrahydroisoquinoline-3-phosphonate derivatives. The target compounds were prepared in good yield using a Pictet-Spengler reaction involving α-amino phosphonates that were easily obtai
Asymmetric hydrogenation of α- And β-enamido phosphonates: Rhodium(I)/monodentate phosphoramidite catalyst
Zhang, Jinzhu,Li, Yang,Wang, Zheng,Ding, Kuiling
, p. 11743 - 11747 (2012/01/03)
High efficiency and enantioselectivity have been achieved in the Rh I-catalyzed asymmetric hydrogenation of α- and β-enamido phosphonates using a monophosphoramidite as the chiral ligand (see scheme; cod=1,5-cyclooctadiene), thus affording the optically active amino phosphonates with a turnover frequency of up to 1800 h-1 and high ee values. Copyright
