775263-49-5

Upstream product

• 17356-08-0 thiourea 
• 456-42-8 m-fluorobenzyl chloride 

Downstream Products

• 40096-23-9 (3-fluorophenyl)methanethiol 
• 124880-29-1 1-(4-Chloro-butylsulfanylmethyl)-3-fluoro-benzene 
• 124880-27-9 1-(4-Chloro-butane-1-sulfinylmethyl)-3-fluoro-benzene 
• 124880-23-5 2-(3-Fluoro-phenyl)-tetrahydro-thiopyran 1-oxide 
• 124879-98-7 (1R,2R)-2-(3-Fluoro-phenyl)-1-oxo-hexahydro-1λ⁴-thiopyran-2-carbothioic acid methylamide 

Relevant academic research and scientific papers

Synthesis and Biological Activity of trans-(+/-)-N-Methyl-2-(3-pirydyl)-2-tetrahydrothiopyrancarbothioamide 1-Oxide (RP 49356) and Analogues: A New Class of Potassium Channel Opener

The synthesis and biological activity of trans-(+/-)-N-methyl-2-(3-pyridyl)-2-tetrahydrothiopyrancarbothioamide 1-oxide (8a, RP 49356) and analoques is reported.These compounds constitute a new structural class of K+-channel opener.The effects of changes in the pyridyl group, thioamide, and thiane ring on in vitro K+-channel opening activity are discussed.A 3-pyridyl or 3-quinolyl group, a small N-alkyl thioamide function, and a thiane oxide ring, in which the sulfoxide is in a trans relationship to thioamide, are preferred for activity.Selected compounds were tested intravenously in the normotensive anaesthetized rat for hypotensive effects, and the activities reflect their in vitro K+-channel opening activity.This led to further evaluation of compound 8a and the selection of the (-)-enantiomer 8b (RP 52891) for development as an antihypertensive and antianginal agent.