77528-40-6

Upstream product

• 123-75-1 pyrrolidine 
• 24686-78-0 1-Benzoyl-4-piperidone 

Downstream Products

• 77528-41-7 2-benzoyl-5-methyl Δ^5,10 octahydroisoquinoline-6-one 
• 77528-42-8 2-benzoyl-5-methyl-decahydroisoquinoline-6-one 
• 77253-64-6 9-hydroxy-11-demethylellipticine 
• 77528-32-6 2-benzoyl-5-methyl-9-methoxy-1,2,3,4,4a,5,11,11a-octahydro-6H-pyrido <4,3-b> carbazole 
• 63081-06-1 11-demethyl-9-methoxy-ellipticine 
• 61675-79-4 3-benzoyl-2,3,4,6-tetrahydrobenzo[c]-2,7-naphthyridin-5(1H)-one 
• 61675-75-0 3-Benzoyl-2,3,4,6-tetrahydro-8,9-dimethoxybenzo<2,7>naphthyridin-5(1H)-one 

Relevant academic research and scientific papers

Substituted 1,2,3,4-tetrahydrobenzo[C][2,7] naphthyridines and derivatives thereof as kinase inhibitors

The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

Furo 3,2-c pyridine derivatives and their use in treating depression and cerebral ischemia

Compounds of general formula (I) STR1 wherein R1 represents a phenyl, halophenyl, methylphenyl, ethylphenyl, methoxyphenyl, trifluoromethylphenyl or naphthyl group, R2 represents hydrogen or a methyl or phenyl group, and R3 represents hydrogen or a benzyl

Synthesis, DNA intercalation and antitumor activity of 9-hydroxy-11-demethylellipticine and some derivatives. Comparison with the corresponding ellipticines

The authors report 3 synthetic routes leading to the 11-demethylellipticines. Their 9-methoxylated and 9-hydroxylated derivatives as well as their quaternary ammonium salts have been compared with the corresponding ellipticine derivatives concerning their DNA affinity, their in vitro cytotoxic action and their in vivo antitumor activity. The experimental results indicate that the 11-demethylellipticines show less DNA affinity but possess a much lower toxicity than the corresponding ellipticines, being at the same time also less active on L 1210 leukemia. It appears that the presence of a methyl group on the intercalating ring (at C-11) plays a major role in determining the biological activity. A similar observation has been made in the actinomycin series.