775288-08-9Relevant academic research and scientific papers
COVALENT TARGETING OF E3 LIGASES
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Paragraph 0591; 0623; 0700; 0742; 0816; 0868-0869, (2020/05/19)
Disclosed herein, inter alia, are compositions and methods for targeting E3 ligases. In an aspect is a targeted protein degrader including 1) a targeted protein binder and 2) an E3 Ubiquitin ligase binder, wherein the E3 Ubiquitin ligase is human RNF4 or human RNF114. In an aspect is provided a pharmaceutical composition including a compound as described herein, including embodiments, and a pharmaceutically acceptable excipient.
Benzenesulphonamide derivatives, method for production and use thereof for treatment of pain
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Page/Page column 13-14, (2008/06/13)
The present invention concerns novel benzenesulphonamide compounds, defined by formula I and the description, their method of preparation and their use in therapy.
