77529-35-2

Upstream product

• 64543-53-9 1,2-dichloro-4-(phenylmethyl)benzene 
• 75-36-5 acetyl chloride 

Downstream Products

• 82760-80-3 methyl 4-[4-(3,4-dichlorophenylmethyl)phenyl]-2,4-dioxo-1-butanoate 
• 77529-37-4 [4-(3,4-Dichloro-benzyl)-phenyl]-acetic acid methyl ester 
• 82760-81-4 4-[4-(3,4-dichlorophenylmethyl)phenyl]-2,4-dioxo-1-butanoic acid 
• 77529-43-2 4-[4-(3,4-dichlorobenzyl)phenyl]-3-hydroxy-3-pyrroline-2,5-dione 
• 77529-39-6 2-[4-(3,4-Dichloro-benzyl)-phenyl]-acetamide 

Relevant academic research and scientific papers

Inhibitors of Glycolic Acid Oxidase. 4-Substituted 2,4-Dioxobutanoic Acid Derivatives

Fourteen new 4-substituted 2,4-dioxobutanoic acids have been synthesized.These compounds, all of which contain lipophilic 4-substituents, are potent inhibitors in vitro of porcine liver glycolic acid oxidase.The I50 value of the two most potent representatives, 4-(4'-bromo-4-yl)-2,4-dioxobutanoic acid (8) and 4-thio>-4-yl>-2,4-dioxobutanoic acid (13) is 6 * 10-8 M.

2,4-Dioxo-4-substituted-1-butanoic acid derivatives useful in treating urinary tract calcium oxalate lithiasis

2,4-Dioxo-4-substituted-1-butanoic acid derivatives of the formula: STR1 where R is hydrogen or C1-4 alkyl; and L is a lipophilic group consisting essentially of: STR2 where R1 and R2 are each independently selected from the group consisting of (a) hydrogen; (b) C4-12 straight or branched chain alkyl; (c) C4-7 cycloalkyl; and (d) tetrahydronaphthyl; provided that R1 and R2 may not both be hydrogen; and when one of R1 or R2 is tetrahydronaphthyl, the other must be some other substituent; and that positions 2 and 6 of the substituted phenyl moiety may not be substituted; and STR3 where R1, and R2 have the same meaning as above except tetrahydronaphthyl; R3 is bromine, chlorine, or fluorine; m is 0 to 3; or a pharmaceutically acceptable salt thereof.