775353-69-0Relevant academic research and scientific papers
Potent and selective proline derived dipeptidyl peptidase IV inhibitors
Edmondson, Scott D.,Mastracchio, Anthony,Beconi, Maria,Colwell Jr., Lawrence F.,Habulihaz, Bahanu,He, Huaibing,Kumar, Sanjeev,Leiting, Barbara,Lyons, Kathryn A.,Mao, Ann,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,Zhu, Lan,Thornberry, Nancy A.,Weber, Ann E.,Parmee, Emma R.
, p. 5151 - 5155 (2007/10/03)
In-house screening of the Merck sample collection identified proline derived homophenylalanine 3 as a DPP-IV inhibitor with modest potency (DPP-IV IC50 = 1.9 μM). Optimization of 3 led to compound 37, which is among the most potent and selectiv
