775354-66-0Relevant academic research and scientific papers
Function-oriented studies targeting pectenotoxin 2: Synthesis of the GH-ring system and a structurally simplified macrolactone
O'Rourke, Natasha F.,Mu,Higgs, Henry N.,Eastman, Alan,Micalizio, Glenn C.
, p. 5154 - 5157 (2017)
A chemical foundation for function-oriented studies of pectenotoxin 2 (PTX2) is described. A synthesis of the bicyclic GH-system, and the design and synthesis of a PTX2-analogue, is presented. While maintaining critical features for actin binding, and lacking the Achilles' heel for the natural product's anticancer activity (the AB-spiroketal), this first-generation analogue did not possess the anticancer properties of PTX2, an observation that indicates the molecular significance of features present in the natural product's CDEF-tetracycle.
Synthesis of new AB2 monomers for polymerization to hyperbranched polymers by 1,3-dipolar cycloaddition
Smet, Mario,Metten, Kris,Dehaen, Wim
, p. 1097 - 1108 (2007/10/03)
A number of AB2 monomers containing either one azide and two acetylene functions or vice versa have been prepared. Upon polymerization, these compounds were found to give rise to hyperbranched oligomers as detected by NMR spectroscopy. However, the formation of high-molecular-weight polymers could not be proven by GPC analysis. Crosslinking was found to be a major drawback of this approach to hyperbranched polymers. Two examples of the interesting situation in which the polymerization already starts during the introduction of the polymerizable group are described.
