77541-70-9Relevant academic research and scientific papers
One-Pot Highly Regioselective Synthesis of Indole-Fused Pyridazino[4,5- b ][1,4]benzoxazepin-4(3 H)-ones by a Smiles Rearrangement
Jiang, Xiaolei,Hu, Fangdong
supporting information, p. 1207 - 1210 (2018/03/23)
A simple and convenient synthesis of indole-fused pyridazino[4,5- b ][1,4]benzoxazepin-4(3 H)-ones is described. A range of 2-(1 H -indol-2-yl)phenols and 4,5-dichloropyridazin-3-ones are compatible with this reaction. A Smiles rearrangement is proposed as a key step in the highly regioselective construction of the products. The easy availability of the starting materials makes this an appealing method in organic synthesis.
Concurrent Alkylation-Methoxylation of 4,5-Dihalopyridazin-6-ones and Synthesis of 5-Halo-4-hydroxypyridazin-6-ones
Cho, Su-Dong,Choi, Woo-Yong,Yoon, Yong-Jin
, p. 1579 - 1582 (2007/10/03)
1-Alkyl-5-halo-4-methoxypyridazin-6-ones were synthesized from 1-alkyl-4,5-dihalopyridazin-6-ones by the concurrent alkylation-methoxylation. 1-Alkyl-5-halo-4-hydroxypyridazin-6-ones were also prepared.
3(2H)Pyridazinone, process for its preparation and anti-allergic agent containing it
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, (2008/06/13)
A 3(2H)pyridazinone of the formula: STR1 wherein R1 is hydrogen, methyl, C3 -C6 alkenyl, C5 or C6 cycloalkyl, benzyl, phenyl, --(CH2)m CO2 R3 (wherein R3 is hydrogen or C1 -C5 alkyl, and m is an integer of from 1 to 4), --(CH2)n A (wherein A is --OH or --N(R4)2 wherein R4 is C1 -C3 alkyl, and n is an integer of from 2 to 6) or --CH2 CF3 ; R2 is chlorine or bromine; each of Y1 and Y2 which may be the same or different, is hydrogen, C1 -C5 alkyl, C2 -C8 alkenyl, halogen, --OR5 (wherein R5 is hydrogen, C1 -C8 alkyl or STR2 wherein q is an integer of from 1 to 4), --CO2 R6 (wherein R6 is hydrogen or C1 -C5 alkyl), --N(R7)2 (wherein R7 is C1 -C4 alkyl) or --SR8 (wherein R8 is C1 -C4 alkyl); and Y3 is C1 -C5 alkyl, C2 -C8 alkenyl, halogen, --OR5 (wherein R5 is as defined above), --CO2 R6 (wherein R6 is as defined above), --N(R7)2 (wherein R7 is as defined above) or --SR8 (wherein R8 is as defined above), or a pharmaceutically acceptable salt thereof.
