77545-18-7

Upstream product

• 77545-17-6 bis-(3'-benzyloxybenzylidene)-succinic acid 
• 115061-18-2 (E)-3-(methoxycarbonyl)-4-(3,4-dimethoxyphe-nyl)but-3-enoic acid 
• 1700-37-4 3-Benzyloxybenzaldehyde 
• 78032-13-0 2-[1-(3-Benzyloxy-phenyl)-meth-(Z)-ylidene]-succinic acid dimethyl ester 
• 78032-12-9 3'-benzyloxybenzylidene succinic acid 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 65859-89-4 (E)-dimethyl-2-(3,4-dimethoxybenzelidene)succinate 

Downstream Products

• 78032-15-2 Acetic acid 3-[(3S,4S)-4-(3-acetoxy-benzyl)-2,5-dioxo-tetrahydro-furan-3-ylmethyl]-phenyl ester 
• 76543-16-3 2,3-bis(3-hydroxybenzyl)-butane-1,4-diol 
• 76543-15-2 trans-2,3-bis[(3-hydroxyphenyl)methyl]-γ-butyrolactone 
• 78032-16-3 Acetic acid 3-[(3S,4S)-4-(3-acetoxy-benzyl)-2-oxo-tetrahydro-furan-3-ylmethyl]-phenyl ester 

Relevant academic research and scientific papers

Synthesis of 3,4-Bis-dihydro-2(3H)-furanones and 2,3-Bis(m- or p-substituted-benzyl)-butane-1,4-diols.

Stobbe condensation of appropriately substituted aromatic aldehydes with diethyl or dimethyl succinate in the presence of sodium methoxide yields the required starting materials for the synthesis of the title compounds.The diacids (1-4) and half acid-half

CHEMICAL SYNTHESIS OF THE FIRST LIGNANS TO BE FOUND IN HUMANS AND ANIMALS

Trans-2,3-bis-(3'-hydroxybenzyl)-butyrolactone (1) and 2,3-bis-(3'-hydroxybenzyl)-butane-1,4-diol (2), recently identified in urine, have been synthesised in racemic form.