65859-89-4

Upstream product

• 115061-18-2 (E)-3-(methoxycarbonyl)-4-(3,4-dimethoxyphe-nyl)but-3-enoic acid 
• 186581-53-3 diazomethane 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 106-65-0 Dimethyl succinate 
• 624-48-6 dimethyl cis-but-2-ene-1,4-dioate 
• 67-56-1 methanol 

Downstream Products

• 93578-31-5 2-[1-(3,4-Dimethoxy-phenyl)-meth-(E)-ylidene]-3-[1-(3,4-dimethoxy-phenyl)-meth-(Z)-ylidene]-succinic acid 4-methyl ester 
• 77545-17-6 bis-(3'-benzyloxybenzylidene)-succinic acid 
• 186411-98-3 2-[(3,4-dimethoxyphenyl)methylene]-1,4-butanediol 
• 77545-18-7 2,3-Bis-(3-hydroxy-benzyl)-succinic acid 

Relevant academic research and scientific papers

Efficient synthesis of lactonic and thionolactoniclignans and evaluation of their anti-oxidant, anti-inflammatory and cytotoxic activities

A short and versatile synthesis of α,β-dibenzyl-γ-butyrolactones has been developed starting from inexpensive materials by applying Stobbe condensation and following the novel reductive cyclisation with sodiumborohydride. Natural products Suchilactone (5a

An Easy Procedure for the Preparation of 3-Methylidenetetrahydrofurans from Dimethyl Succinates

A new synthetic proceduree to obtain 3-methylidenetetrahydrofurans is described, in which the methylidene group is generated during the formation of the tetrahydrofuran ring. These are prepared by reduction of differently substituted dimethyl succinates obtained by Stobbe condensation.

Synthesis of 3,4-Bis-dihydro-2(3H)-furanones and 2,3-Bis(m- or p-substituted-benzyl)-butane-1,4-diols.

Stobbe condensation of appropriately substituted aromatic aldehydes with diethyl or dimethyl succinate in the presence of sodium methoxide yields the required starting materials for the synthesis of the title compounds.The diacids (1-4) and half acid-half