77547-07-0

Usage

Uses

Used in Flavor and Fragrance Industry:
5-Benzyl-3-methylene-dihydro-furan-2-one is used as a flavoring agent and fragrance in various food and cosmetic products. Its pleasant scent and taste make it a popular choice for enhancing the sensory experience of these products.
Used in Perfumery:
In the perfumery industry, 5-Benzyl-3-methylene-dihydro-furan-2-one is used as a key ingredient in the formulation of perfumes. Its sweet, floral, and slightly spicy aroma contributes to the overall scent profile, creating a unique and appealing fragrance.
Used in Personal Care Products:
5-Benzyl-3-methylene-dihydro-furan-2-one is also utilized in the development of personal care products such as soaps, lotions, and creams. Its pleasant scent and compatibility with other ingredients make it an ideal component for these products.
Used in Pharmaceutical Development:
This chemical compound is used in the pharmaceutical industry for its potential therapeutic properties. Its versatile chemical structure allows for its use in the development of new drugs and medications.
Used as an Intermediate in Organic Synthesis:
5-Benzyl-3-methylene-dihydro-furan-2-one serves as an intermediate in organic synthesis, enabling the creation of a wide range of chemical products. Its unique structure and properties make it a valuable component in various chemical reactions and processes.

InChI:InChI=1/C12H12O2/c1-9-7-11(14-12(9)13)8-10-5-3-2-4-6-10/h2-6,11H,1,7-8H2

Upstream product

• 96-09-3 styrene oxide 
• 17435-72-2 ethyl 2-bromomethyl-2-propenoate 
• 72707-66-5 2-(bromomethyl)acrylic acid 
• 122-78-1 phenylacetaldehyde 
• 838850-83-2 ethyl 2-diethoxyphosphoryl-5-phenyl-4-nitropentanoate 
• 838850-94-5 ethyl 2-diethoxyphosphoryl-4-oxo-5-phenylpentanoate 
• 50-00-0 formaldehyd 
• 838851-03-9 (5-benzyl-2-oxotetrahydrofuran-3-yl)-phosphonic acid diethyl ester 
• 368452-81-7 2-Methylene-4-nitro-5-phenyl-pentanoic acid ethyl ester 

Relevant academic research and scientific papers

A new synthesis of exo-methylene butyrolactones from nitroalkanes

A versatile route to exo-methylene butyrolactones was developed by employing a three step reaction sequence consisting of Michael addition of primary nitroalkanes 1 to ethyl (2-bromomethyl) acrylate (2), then Nef conversion of the nitro derivatives 3, and subsequent lactonization of the obtained keto esters 4. The method is chemoselective for important functionalities such as ester, C=C double bond and hydroxyl.

New antifungal scaffold derived from a natural pharmacophore: Synthesis of α-methylene-γ-butyrolactone derivatives and their antifungal activity against Colletotrichum lagenarium

Thirty new and thirty-four known analogues were designed and synthesized to improve the potential use of the α-methylene-γ-butyrolactone ring, a natural pharmacophore. All structures were confirmed by 1H and 13C NMR, MS, and single-c

Novel synthesis, cytotoxic evaluation, and structure-activity relationship studies of a series of α-alkylidene-γ-lactones and lactams

5-Alkyl- and 5-arylalkyl-3-methylenedihydrofuran-2-ones 13a-e, 3-alkylidenedihydrofuran-2-ones 18a-c, and 3-methylenepyrrolidin-2-ones 16a-e were synthesized utilizing ethyl 2-diethoxyphosphoryl-4-nitroalkanoates 9a-e as common intermediates. All obtained

2-Diethoxyphosphoryl-4-nitroalkanoates - Versatile intermediates in the synthesis of α-alkylidene-γ-lactones and lactams

Michael addition of various nitroalkanes 7a-f to ethyl (2- diethoxyphosphoryl)acrylate (6) gave 2-diethoxyphosphoryl-4-nitroalkanoates 8a-f. Transformation of the nitro functionality into hydroxy or amino group and cyclization yielded 3-(diethoxyphosphory

A New Synthesis of γ-Substituted α-Methylene-γ-butyrolactones (2-Methylene-4-alkanolides) using Catalysis by SnCl2/Amberlyst 15

Reaction of α-bromomethylacrylic acid with aldehydes or ketones in an SnCl2/amberlyst 15/THF/H2O system affords 2-methylene-4-alkanolides in mostly good yields.

An SnCl2-Promoted α-Methylene-γ-butirolactone Synthesis in an Aqueous Medium

Reaction of α-bromomethylacrylic acid with aldehydes in an SnCl2-MeOCH2CH2OH-H2O system provides γ-substituted-α-methylene-γ-butirolactones.

REFORMATSKY-TYPE REACTIONS IN AQUEOUS MEDIA. USE OF BROMOMETHYLACRYLIC ACID FOR THE SYNTHESIS OF α-METHYLENE-γ-BUTYROLACTONES.

A new method for the preparation of α-methylene-γ-butyrolactones is described.