838850-83-2Relevant academic research and scientific papers
Novel synthesis, cytotoxic evaluation, and structure-activity relationship studies of a series of α-alkylidene-γ-lactones and lactams
Janecki, Tomasz,B?aszczyk, Edyta,Studzian, Kazimierz,Janecka, Anna,Krajewska, Urszula,Rózalski, Marek
, p. 3516 - 3521 (2007/10/03)
5-Alkyl- and 5-arylalkyl-3-methylenedihydrofuran-2-ones 13a-e, 3-alkylidenedihydrofuran-2-ones 18a-c, and 3-methylenepyrrolidin-2-ones 16a-e were synthesized utilizing ethyl 2-diethoxyphosphoryl-4-nitroalkanoates 9a-e as common intermediates. All obtained
2-Diethoxyphosphoryl-4-nitroalkanoates - Versatile intermediates in the synthesis of α-alkylidene-γ-lactones and lactams
B?aszczyk, Edyta,Krawczyk, Henryk,Janecki, Tomasz
, p. 2685 - 2688 (2007/10/03)
Michael addition of various nitroalkanes 7a-f to ethyl (2- diethoxyphosphoryl)acrylate (6) gave 2-diethoxyphosphoryl-4-nitroalkanoates 8a-f. Transformation of the nitro functionality into hydroxy or amino group and cyclization yielded 3-(diethoxyphosphory
