7755-01-3

Basic information

• Product Name: Protopanaxadiol
• Synonyms: Protopanaxadiol;20R-Betulafolienetriol;(20R)-5α-Dammar-24-ene-3β,12β,20-triol;(20R)-Dammar-24-ene-3β,12β,20-triol;(20R)-Protopanaxadiol;20R-Protopanaxadiol;PROTOVERATRINE A+B (RG)(CALL);Protopanaxadiol, 98%, from Panax ginseng C. A. Mey.
• CAS NO: 7755-01-3
• Molecular Formula: C₃₀H₅₂O₃
• Molecular Weight: 460.73208
• Product Categories: Miscellaneous Natural Products;Ginseng series
• Mol File: 7755-01-3.mol

Chemical Properties

• Boiling Point: 559.5 °C at 760 mmHg
• Flash Point: 226.1 °C
• Appearance: /
• Density: 1.036 g/cm³
• Vapor Pressure: 7.57E-15mmHg at 25°C
• Refractive Index: 1.528
• Storage Temp.: 2-8°C
• PKA: 14.96±0.70(Predicted)
• CAS DataBase Reference: Protopanaxadiol(CAS DataBase Reference)
• NIST Chemistry Reference: Protopanaxadiol(7755-01-3)
• EPA Substance Registry System: Protopanaxadiol(7755-01-3)

Safety Data

• Hazardous Substances Data: 7755-01-3(Hazardous Substances Data)

Usage

Description

(20)R-Protopanaxadiol is a sapogenin that has been found in P. ginseng and has anticancer and antibacterial activities. It has a cytotoxic concentration (CC50) value of 6.1 μM in MT-4 human T cell leukemia cells and inhibits the growth of several additional cancer cell lines, including A549 human lung carcinoma, SKOV3 human ovarian adenocarcinoma, SK-Mel-2 human melanoma, P388 and L1210 murine leukemia, and K562 human chronic leukemia cells (ED50s = 11-26 μM). (20)R-protopanaxadiol also inhibits the growth of H. pylori in vitro (MICs = 50-100 μg/ml).

Uses

20(R)-Protopanaxdiol is a saponin ginsenoside which is a signature phytochemical of Ginseng, an herbaceous plant. Anti-cancer agent.

Definition

ChEBI: A diastereomer of protopanaxadiol in which the 20-hydroxy substituent has been introduced at the pro-R position.

InChI:InChI=1/C30H52O3/c1-19(2)10-9-14-30(8,33)20-11-16-29(7)25(20)21(31)18-23-27(5)15-13-24(32)26(3,4)22(27)12-17-28(23,29)6/h10,20-25,31-33H,9,11-18H2,1-8H3/t20-,21+,22?,23+,24-,25-,27-,28+,29-,30+/m0/s1