77556-55-9

Upstream product

• 57384-84-6 1-benzyl-6-chloro-1H-benzo[d][1,3]oxazine-2,4-dione 
• 58607-90-2 5-oxo-2-pyrazoline-3-carboxylic acid,ethyl ester 
• 4743-17-3 5-Chloroisatoic anhydride 
• 620-05-3 iodomethylbenzene 

Downstream Products

• 77422-96-9 4-Benzyl-7-chloro-9-oxo-4,9-dihydro-pyrazolo[5,1-b]quinazoline-2-carboxylic acid 

Relevant academic research and scientific papers

Reactions of 2H-3,1-Benzoxazine-2,4-(1H)dione (Isatoic Anhydride) (1) with Anions of 1,4-Dihydro-5H-Pyrazol-5-ones: Synthesis of Pyrazoloquinazolin-9-ones

Reactions of 2H-3,1-benzoxazine-2,4-(1H)dione (isatoic anhydride) (1) with anions of 1,4-dihydro-5H-pyrazol-5-ones (2) gave pyrazoloquinazolin-9-ones (3) via the nucleophilic attack of the anion 2b rather than 2a.However, in the case of 5-methoxyis

Pyrazoloquinazolin-9-ones: A New Series of Antiallergic Agents

A new series of antiallergic agents, pyrazoloquinazolin-9-ones, was synthesized and evaluated for inhibitory effects in the rat reaginic passive cutaneous anaphylaxis (PCA) screen.Several analogues were found to be more potent than cromolyn sodium intravenously.Structure-activity relationships are discussed.One of the compounds, 4,9-dihydro-5-methoxy-9-oxopyrazoloquinazoline-2-carboxylic acid (36), was found to be approximately 250 times more potent than cromolyn sodium intravenously.