57384-84-6

Upstream product

• 4743-17-3 5-Chloroisatoic anhydride 
• 620-05-3 iodomethylbenzene 
• 100-39-0 benzyl bromide 
• 26960-68-9 1-benzyl-5-chloroisatin 

Downstream Products

• 144129-01-1 10-Benzyl-7-chloro-3-(4-trifluoromethyl-phenyl)-3,4-dihydro-2H,10H-acridine-1,9-dione 
• 77556-55-9 4-Benzyl-7-chloro-9-oxo-4,9-dihydro-pyrazolo[5,1-b]quinazoline-2-carboxylic acid ethyl ester 
• 77422-96-9 4-Benzyl-7-chloro-9-oxo-4,9-dihydro-pyrazolo[5,1-b]quinazoline-2-carboxylic acid 
• 77423-05-3 4-Benzyl-7-chloro-9-oxo-4,9-dihydro-pyrazolo[5,1-b]quinazoline-2-carboxylic acid (1H-tetrazol-5-yl)-amide 
• 1407753-35-8 C₂₆H₃₀ClN₃O₄ 
• 1407753-23-4 C₂₂H₂₃ClN₂O₂ 
• 1452386-65-0 13-benzyl-5-(tert-butylimino)-10-chloro-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one 
• 1452386-66-1 13-benzyl-10-chloro-5-(cyclohexylimino)-6-phenyl-5,6,13,13a-tetrahydro-8H-phthalazino[1,2-b]quinazolin-8-one 
• 1452386-55-8 1-benzyl-2-(2-bromophenyl)-6-chloro-3-(phenylamino)-2,3-dihydroquinazolin-4(1H)-one 

Relevant academic research and scientific papers

Recyclable (PhSe)2-catalyzed selective oxidation of isatin by H2O2: a practical and waste-free access to isatoic anhydride under mild and neutral conditions

After a series of careful conditional optimizations and catalyst screenings, a methodology to prepare isatoic anhydrides through organoselenium-catalyzed selective oxidation of isatins by H2O2 under mild and neutral conditions was developed. The reactions were very practical because of the recyclability of the catalyst and solvent and the convenient isolation procedures of the products. This work reports the organoselenium-catalyzed oxidation of heterocycles that greatly expands the application scopes of organoselenium catalysis. It also indicates that the organoselenium catalysts are robust enough to be recycled in industrial production if suitable isolation procedures are developed.

Identification and development of the 1,4-benzodiazepin-2-one and quinazoline-2,4-dione scaffolds as submicromolar inhibitors of HAT

A library of 1,4-benzodiazepines has been synthesised and evaluated for activity against Trypanosoma brucei, a causative parasite of Human African Trypanosomiasis (HAT). The most potent of these derivatives has an MIC value of 0.97 μM. Herein we report the design, synthesis and biological evaluation of the abovementioned compounds.

INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR AND METHODS FOR IDENTIFYING THE SAME

Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures (Ia), (Ib) including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.

Pyrazoloquinazolin-9-ones: A New Series of Antiallergic Agents

A new series of antiallergic agents, pyrazoloquinazolin-9-ones, was synthesized and evaluated for inhibitory effects in the rat reaginic passive cutaneous anaphylaxis (PCA) screen.Several analogues were found to be more potent than cromolyn sodium intravenously.Structure-activity relationships are discussed.One of the compounds, 4,9-dihydro-5-methoxy-9-oxopyrazoloquinazoline-2-carboxylic acid (36), was found to be approximately 250 times more potent than cromolyn sodium intravenously.