7757-97-3Relevant academic research and scientific papers
MULTIBIOTIC AGENTS AND METHODS OF USING THE SAME
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Page/Page column 117, (2019/01/06)
Multibiotic agents are disclosed. The multibiotic agents may contain two or more moieties linked through bonds cleavable in vivo. The bonds cleavable in vivo can be ester bonds, amide bonds, azo bonds, glycosidic bonds, carbonate linkers, or carbamate linkers. The moieties can be alcohol cores, amine cores, and/or acyls. Also disclosed are compositions containing multibiotic agents and methods of using the multibiotic agents.
Irreducible Analogues of Mevaldic Acid Coenzyme A Hemithioacetal as Potential Inhibitors of HMG-CoA Reductase. Synthesis of a Carbon-Sulfur Interchanged Analogue of Mevaldic Acid Pantetheine Hemithioacetal
Fischer, Gordon C.,Turakhia, Rajesh H.,Morrow, Cary J.
, p. 2011 - 2019 (2007/10/02)
Synthesis of (3,5)-threo- and (3,5)-erythro-6-propanamido>methyl>thio>-3,5-dihydroxy-3-methylhexanoic acid, threo- and erythro-7d, as well as the corresponding δ-lactones, cis- and trans-13a, is described.The key step in the syntheses is the selective amidomethylation of the sulfhydryl in cis- or trans-4-hydroxy-6-(mercaptomethyl)-4-methyl-3,4,5,6-tetrahydro-2H-pyran-2-one, cis- or trans-13d, with N-(hydroxymethyl)pantothenamide, 23.The target compounds are the first in a class being explored as potential inhibitors of HMG-CoA reductase, the key regulated enzyme in cholesterol biosynthesis.They are structurally identical with mevaldic acid pantetheine hemithioacetal, 2b (a known substrate for the enzyme and an analogue of the enzyme-bound intermediate 2a), but they are unable to be reduced by the enzyme because the labile C-S bond in 2b has been replaced with a stable C-C bond in 7d by interchanging a carbon and a sulfur atom.
