77588-53-5Relevant academic research and scientific papers
Detrifluoroacetylation Reaction of Trifluoromethyl-β-diketones: Facile Method for the Synthesis of Succinimide Derivatives and 1,4-Diketones
Wang, Li-Hua,Zhao, Jing
supporting information, p. 4345 - 4348 (2018/08/31)
Currently, a great deal of research efforts are focused on C–C bond activation for development of novel synthetic methodology. In this paper, a detrifluoroacetylation of trifluoromethyl-β-diketones is described, which allows for the synthesis of succinimides and 1,4-diketones through cascade Michael addition/retro-Claisen reaction and nucleophilic substitution/retro-Claisen reaction. The readily available trifluoromethyl-β-diketones, wide substrate scope, and mild conditions make this method very practical.
Synthesis of water-tolerant indium homoenolate in aqueous media and its application in the synthesis of 1,4-dicarbonyl compounds via palladium-catalyzed coupling with acid chloride
Shen, Zhi-Liang,Goh, Kelvin Kau Kiat,Cheong, Hao-Lun,Wong, Colin Hong An,Lai, Yin-Chang,Yang, Yong-Sheng,Loh, Teck-Peng
supporting information; experimental part, p. 15852 - 15855 (2011/01/10)
The first water-tolerant, ketone-type indium homoenolate was synthesized via the oxidative addition of In/InCl3 to enones. The reaction proceeds exclusively in aqueous media. Both indium and indium(III) chloride are necessary for the smooth conversion of the reaction. Similar results were obtained when InCl or InCl2 was used in place of In/InCl3. The synthetic utility of the indium homoenolate was demonstrated through the synthesis of 1,4-dicarbonyl compounds via palladium-catalyzed coupling of indium homoenolate with acid chloride.
SYNTHESIS OF UNSYMMETRICAL 1,4-DIKETONES VIA THE MICHAEL-STETTER REACTION
Phillips, Richard B.,Herbert, Sue A.,Robichaud, Albert J.
, p. 411 - 418 (2007/10/02)
The cyanide catalyzed 1,4-Michael addition of aldehydes to α,β-unsaturated ketones has been examined with regard to substituent effects.Adjustment of the donor/acceptor relationship aloows for the synthesis of multisubstituted diaryl 1,4-diketones.
Addition of Aldehydes to Activated Double Bonds, XXV. Syntheses and Reactions of Branched Tricarbonyl Compounds
Stetter, Hermann,Jonas, Friedrich
, p. 564 - 580 (2007/10/02)
Thiazolium salt-catalyzed addition of aldehydes to arylidene- and alkylidene-β-dicarbonyl compounds as well as to 3-acylacrylic esters leads to branched tricarbonyl compounds (1 - 26), which are useful reagents for the synthesis of heterocyclic compounds.
