77599-17-8

Basic information

• Product Name: Panomifene
• Synonyms: Panomifene;2-[2-[4-[(E)-3,3,3-trifluoro-1,2-diphenylprop-1-enyl]phenoxy]ethylamino]ethanol
• CAS NO: 77599-17-8
• Molecular Formula: C25H24F3NO2
• Molecular Weight: 427.464
• Mol File: 77599-17-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 550.7°C at 760 mmHg
• Flash Point: 286.9°C
• Appearance: /
• Density: 1.203g/cm³
• Vapor Pressure: 5.79E-13mmHg at 25°C
• Refractive Index: 1.567
• CAS DataBase Reference: Panomifene(CAS DataBase Reference)
• NIST Chemistry Reference: Panomifene(77599-17-8)
• EPA Substance Registry System: Panomifene(77599-17-8)

Safety Data

• Hazardous Substances Data: 77599-17-8(Hazardous Substances Data)

Usage

Uses

Panomifene is an analogue to tamoxifen (T006000), an antiestrogen currently used as a therapeutic agent against breast cancer, and there are some similar routes in their metabolism.

InChI:InChI=1/C25H24F3NO2/c26-25(27,28)24(21-9-5-2-6-10-21)23(19-7-3-1-4-8-19)20-11-13-22(14-12-20)31-18-16-29-15-17-30/h1-14,29-30H,15-18H2/b24-23+

Upstream product

• 141-43-5 ethanolamine 
• 179031-96-0 (E)-3,3,3-trifluoro-1-[4-(2-chloroethoxy)phenyl]-1,2-diphenylpropene 
• 179032-00-9 (E)-3,3,3-trifluoro-1-[4-(2-hydroxyethoxy)phenyl]-1,2-diphenylpropene 
• 154669-95-1 3,3,3-trifluoro-1,2-diphenylpropan-1-one 
• 79258-51-8 (E)-1,2-diphenyl-3,3,3-trifluoro-1-(4-hydroxyphenyl)-propene 
• 36029-60-4 (E)-3,3,3-trifluoro-1-(4-methoxyphenyl)-1,2-diphenylpropene 
• 591-50-4 iodobenzene 
• 867182-60-3 (Z)-3,3,3-trifluoro-2-iodo-1-[4-(2-chloroethoxy)phenyl]-1-phenylpropene 
• 867182-59-0 (Z)-3,3,3-trifluoro-2-iodo-1-(4-methoxyphenyl)-1-phenylpropene 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 772-62-3 3,3,3-trifluoro-1-phenylpropyne 

Relevant articles and documents

Highly regio- and stereo-selective carbometallation reaction of fluorine-containing internal acetylenes with organocopper reagents

The carbometallation reactions of fluoroalkylated internal alkynes with various organocopper reagents derived from organolithium, Grignard, and organozinc reagents were examined. All carbocupration reactions proceeded smoothly in a highly regio- and stereo-selective manner to give the corresponding vinylcopper intermediates. The intermediates reacted with H + smoothly, leading to the trisubstituted alkenes in high to excellent yields, whereas they reacted only with strictly limited carbon electrophiles such as allyl-, crotyl-, methallyl bromide, etc, probably due to the low reactivity exerted by an electron-withdrawing fluoroalkyl group. Treatment of vinylcopper with iodine resulted in a high yield of the corresponding vinyl iodide, which was employed successfully for Suzuki-Miyaura and Sonogashira cross-coupling reactions. In addition, two key reactions, the carbocupration and the Suzuki-Miyaura cross-coupling reaction realized the first highly stereoselective total synthesis of anti-estrogen drug, panomifene.

A highly regio- and stereoselective carbocupration of fluoroalkylated internal alkynes: A short total synthesis of the antiestrogenic drug panomifene

(Equation presented) A highly regio- and stereoselective carbometalation reaction of fluoroalkylated internal alkynes with organocopper reagents is described. This reaction is utilized successfully in the short, stereoselective total synthesis of the antiestrogenic drug panomifene.

New practical synthesis of panomifene. The effect of 2-trifluoromethyl substituent on the stereoselectivity of dehydration of 1,1,2-triarylethanols

Highly stereoselective eliminations were achieved by acid-catalysed dehydration of 1-(4-alkoxy)-3,3,3-trifluoro-1,2-diphenylpropan-1-ols (10, 11, 15). The influence of the trifluoromethyl group on the stereochemistry of the elimination has been discussed. The observed high stereoselectivity has been applied to give a new, practical synthesis of antiestrogenic drug panomifene (1).