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ACYLATION OF ACYCLIC ENAMINES WITH AN EXCESSIVE AMOUNT OF PYRIDINECARBONYL CHLORIDES
Naito, Takeaki,Ninomiya, Ichiya
, p. 735 - 738 (2007/10/02)
Acylation of the acyclic enamines (1a and d) and (6a) with an excessive amount of isonicotinoyl or nicotinoyl chloride provided a simple preparation of the spiranes (2, 3, and 7) or the 1,6-naphtyridines (4 and 5) respectively, of which the latter has an analogous structure of nalidixic acid, a powerful antibacterial agent.
