77603-40-8Relevant academic research and scientific papers
ANTIMICROBIAL AGENTS FROM HIGHER PLANTS. NEW SYNTHESIS AND BIOACTIVITY OF TRYPTANTHRIN (INDOLO--QUINAZOLIN-6,12-DIONE) AND ITS ANALOGUES.
Mitscher, Lester A.,Wong, Wai-Cheong,DeMeulenaere, Teresa,Sulko, Jerzy,Drake, Stephen
, p. 1017 - 1021 (2007/10/02)
Base-catalyzed condensation of substituted isatins and substituted isatoic anhydrides provides a convenient, one-step flexible synthesis of indolo--quinazolin-6,12-diones, including the antifungal natural product tryptanthrin.This new process provides the basis for a systematic exploration of the relationship between structure and antimicrobial activity.Preliminary findings demonstrate that non-symmetrically substituted analogues are easily prepared and the method tolerates the presence of a variety of ring substituents.
