77604-71-8Relevant academic research and scientific papers
Stable Sulfur Ylides. VIII. The reactions of 1,3-Oxazin-4-one Derivatives
Kinoshita, Toshio,Sasada, Yutaka,Watanabe, Mitsuaki,Furukawa, Sunao
, p. 2892 - 2899 (2007/10/02)
6-Methyl-5-methylthio-2-methyl-1,3-oxazin-4-one (1) was treated with acid to give 4-methyl-5-methylthio-3-pyridine-2,6(1H,3H)-dione (2) in good yield.Similarly, 2-aminopyridine derivatives (7a-e) were obtained by the reaction of 1 with various amines.On the thermolysis of 1,3-methylthio-2--3,5-dioxohexanitrile (12) was obtained.When 1 was treated with trifluoro-acetic anhydride, a trifluoroacetyl group was introduced at the active methine moiety of 1.No ring conversion occured in the reaction of 6-methyl-5-methylthio-2-methyl-1,3-oxazin-4-one (13) with various reagents, whereas ring cleavage of the 1,3-oxazine ring of 13 was observed.Dimethylsulfonium acetyl-N-phenylcarbamoylmethylide (18) was treated with quinoline-1-oxide and acetyl chloride to give 4-methyl-3-methylthio-1-phenyl-5-pyridine-2,6(1H,5H)-dione (20) instead of the 1,3-oxazin-4-one derivative (19).
