77607-68-2

Basic information

• Product Name: 2-amino-3-cyano-4-(2'-furyl)-6-phenyl-pyridine
• Synonyms: 2-amino-3-cyano-4-(2'-furyl)-6-phenyl-pyridine
• CAS NO: 77607-68-2
• Molecular Weight: 261.283
• Mol File: 77607-68-2.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2-amino-3-cyano-4-(2'-furyl)-6-phenyl-pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-3-cyano-4-(2'-furyl)-6-phenyl-pyridine(77607-68-2)
• EPA Substance Registry System: 2-amino-3-cyano-4-(2'-furyl)-6-phenyl-pyridine(77607-68-2)

Safety Data

• Hazardous Substances Data: 77607-68-2(Hazardous Substances Data)

Upstream product

• 3237-22-7 2-cyano-3-(2-furanyl)acrylonitrile 
• 98-86-2 acetophenone 
• 2975-99-7 2-furyl phenylethynyl ketone 
• 109-77-3 malononitrile 
• 98-01-1 furfural 
• 156605-56-0 1-phenylethan-1-one O-pivaloyl oxime 
• 717-21-5 3-(furan-1-yl)-1-phenyl-prop-2-en-1-one 

Downstream Products

• 281225-31-8 5-furan-2-yl-3-(4-methoxy-phenyl)-7-phenyl-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one 
• 281225-30-7 5-furan-2-yl-3-(2-methoxy-phenyl)-7-phenyl-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one 
• 77607-78-4 2-Amino-4-furan-2-yl-6-phenyl-nicotinamide 

Relevant articles and documents

Synthesis of Some Novel Pyrido[2,3-d]pyrimidine and Pyrido[3,2-e][1,3,4]triazolo and Tetrazolo[1,5-c]pyrimidine Derivatives as Potential Antimicrobial and Anticancer Agents

A novel series of pyrido[2,3-d]pyrimidines 3a–d, 4a–d, 5a–d, 6a–d, and 7a–d; pyrido[3,2-e][1,3,4]triazolo; and tetrazolo[1,5-c]pyrimidines 10a–d and 11a–d was synthesized through different chemical reactions starting from 2-amino-3-cyano-4,6-diarylpyridines. The newly synthesized heterocycles were characterized by elemental analysis, IR, 1H-NMR, 13C-NMR, and mass spectral data. Compounds have been screened for their antibacterial and antifungal activities. The data showed that the presence of electron-donating group such as p-methoxyphenyl increases the antimicrobial activity. Also, the compounds have shown anticancer activity for colon and liver cancer cells.

Triarylimidazo[1,2-a]pyridine-8-carbonitriles: solvent-free synthesis and their anti-cancer evaluation

In this study, we have presented the synthesis of novel 2,5,7-triarylimidazo[1,2-a]pyridine-8-carbonitriles from 2-amino-4,6-diarlypyridine-3-carbonitrile and nitrostyrene using FeCl3 (20 mol%) as Lewis acid under solvent-free conditions. A library of compounds with diverse substitutions have also been synthesized and screened for in-vitro anti-cancer activity against various cell lines such as A549 (Lung), HCT-116 (Colon), SW-620 (Colon), and MIAPACA (Pancreas).

Urease-catalyzed synthesis of aminocyanopyridines from urea under fully green conditions

This is an original work on catalytic performance of urease in organic synthesis which in one-pot dissociation of urea and condensation of the in situ generated ammonia with aldehydes, acetophenones, and malononitrile occurs in water to give 2-amino-3-cyanopyridines. Comparative experiments with ammonium salts supported the enzymatic specify of 0.01 g/mL (50 U/mg) of urease for bio-production of ammonia, while trace amount of heavy metal ions such as Pb2+, Hg2+, and Ag+ inhibit these specific reactions. The scalability and promiscuity of urease facilitate the applicability of the process for biotechnological organic reactions based on ammonia.