77607-72-8Relevant academic research and scientific papers
Synthesis of Some Polysubstituted Nicotinonitriles and Derived Pyrido[2,3-d]pyrimidines as in Vitro Cytotoxic and Antimicrobial Candidates
Faidallah, Hassan M.,Rostom, Sherif A. F.,Khan, Khalid A.
, (2016)
The synthesis of polysubstituted pyridines, in addition to some derived pyrido[2,3-d]pyrimidine ring systems supported with chemotherapeutically active functionalities, is described. They were evaluated for their in vitro cytotoxic effects against three d
Malononitriles & Cyanoesters : Part VI - Synthesis of New Biologically Active Cyanopyridines
Latif, N.,Mishriky, N.,Girgis, N. S.
, p. 147 - 149 (2007/10/02)
3-(2'-Furyl)- and 3-(2'-thienyl)-acrylophenones (I) react with malononitrile in the presence of ammonium acetate to give 2-amino-3-cyano-4,6-disubstituted-pyridines (II).The latter are hydrolysed with alkali to give the corresponding nicotinamides (IV).Th
