77611-56-4Relevant academic research and scientific papers
Ligand-Accelerated Iron Photocatalysis Enabling Decarboxylative Alkylation of Heteroarenes
Li, Zhenlong,Wang, Xiaofei,Xia, Siqi,Jin, Jian
supporting information, (2019/06/13)
A mild, practical protocol for the decarboxylative alkylation of heteroarenes has been accomplished via iron photocatalysis. A diverse range of carboxylic acids readily undergo oxidative decarboxylation and then couple with a broad array of heteroarenes in this transformation. The photoexcited state lifetimes of iron complexes are typically much shorter than those of iridium and ruthenium complexes. Here we describe our effort on iron photocatalysis by utilizing the intramolecular charge transfer pathway of iron-carboxylate complexes.
New General Processes of Homolytic Alkylation of Heteroaromatic Bases by t-BuOOH or (t-BuO)2 and Alkyl Iodides
Fontana, Francesca,Minisci, Francesco,Barbosa, Maria Claudia Nogueira,Vismara, Elena
, p. 995 - 999 (2007/10/02)
New general, selective processes of homolytic alkylation of protonated heteroaromatic bases have been developed using alkyl iodides and t-BuOOH or (t-BuO)2 as sources of alkyl radicals.Both processes are based on the generation of methyl radical from the peroxides, and on iodine abstraction from the alkyl iodide by the methyl radical.The selective processes are the result of combined enthalpic and polar effects.The enthalpic factor governs the equilibrium of iodine abstraction, whereas the polar effect governs the reactivity of the alkyl radicals with the protonated heteroaromatic ring.A redox chain is operative with t-BuOOH and an unusual free-radical chain process is involved with (t-BuO)2.Both chains are particularly effective because of the electron-transfer oxidation of the pyridyl radical intermediate, the ionization potential of which (5.4-6.0 eV) is close to that of lithium (5.39 eV) or sodium (5.14 eV).
