77614-79-0

Basic information

• Product Name: 3,5-bis(difluoromethyl)-1H-pyrazole(SALTDATA: FREE)
• Synonyms: 3,5-bis(difluoromethyl)-1H-pyrazole(SALTDATA: FREE)
• CAS NO: 77614-79-0
• Molecular Formula: C₅H₄F₄N₂
• Molecular Weight: 168.0922728
• Mol File: 77614-79-0.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 207.4℃ at 101.3kPa
• Appearance: /
• Density: 1.59 at 20℃
• Vapor Pressure: 0.78-8.5Pa at 20-50℃
• CAS DataBase Reference: 3,5-bis(difluoromethyl)-1H-pyrazole(SALTDATA: FREE)(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-bis(difluoromethyl)-1H-pyrazole(SALTDATA: FREE)(77614-79-0)
• EPA Substance Registry System: 3,5-bis(difluoromethyl)-1H-pyrazole(SALTDATA: FREE)(77614-79-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 77614-79-0(Hazardous Substances Data)

Usage

General Description

3,5-bis(difluoromethyl)-1H-pyrazole, also known as SALTDATA: FREE, is a chemical compound used in various industrial and research applications. 3,5-bis(difluoromethyl)-1H-pyrazole(SALTDATA: FREE) is a pyrazole derivative containing two difluoromethyl groups. It is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. 3,5-bis(difluoromethyl)-1H-pyrazole(SALTDATA: FREE) has been found to exhibit diverse biological activities, including antimicrobial, antifungal, and pesticidal properties. Additionally, it has potential applications in materials science, such as in the development of novel polymers and additives. Due to its versatility and wide range of applications, 3,5-bis(difluoromethyl)-1H-pyrazole is an important component in the chemical industry.

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Downstream Products

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Relevant articles and documents

A Major Advance in the Synthesis of Fluoroalkyl Pyrazoles: Tuneable Regioselectivity and Broad Substitution Patterns

A novel approach towards highly functionalized fluoroalkyl pyrazoles was developed by using fluoroalkyl amino reagents in combination with a variety of fluorinated ketimines. Tuneable introduction of fluoroalkyl groups in the 3- and 5-positions was possible by using vinamidinium intermediates or the corresponding enamino ketones after hydrolysis. These high-value building blocks can give rise to a large number of analogues for bioactivity screening and discovering new heterocyclic bioactive ingredients in various life science fields.

METHOD FOR THE PRODUCTION OF 3,5-BIS(FLUOROALKYL)PYRAZOLE DERIVATIVES

The present invention describes a novel method for preparing 3,5-bis(fluoroalkyl)pyrazole derivatives.

A General Approach towards NH-Pyrazoles That Bear Diverse Fluoroalkyl Groups by Means of Fluorinated Iminium Salts

A new and general approach to important fluoroalkyl-substituted pyrazoles has been developed. The approach is based on the use of fluoroalkyl amino reagents and their Lewis acid activation to form a fluoroalkyl iminium salt that acts as a formal "fluoroacyl transfer reagent". Their interaction with readily available fluoroalkyl azines followed by spontaneous cyclization of the formed intermediates under acidic conditions leads to the formation of 3,5-disubstituted pyrazoles. The reaction is extremely versatile, high yielding, and allows quick access to pyrazoles that bear two fluoroalkyl functionalities (identical or different). These compounds are otherwise difficult to prepare. The reaction is scalable and suitable for industrial production.