77614-79-0

Usage

Uses

Used in Pharmaceutical Industry:
3,5-bis(difluoromethyl)-1H-pyrazole(SALTDATA: FREE) is used as a building block for the synthesis of various pharmaceuticals, leveraging its chemical structure to create new drugs with potential therapeutic benefits.
Used in Agrochemical Industry:
In the agrochemical sector, 3,5-bis(difluoromethyl)-1H-pyrazole(SALTDATA: FREE) is utilized as a component in the development of agrochemicals, such as pesticides and fungicides, due to its antimicrobial and antifungal properties, which contribute to crop protection and yield enhancement.
Used in Materials Science:
3,5-bis(difluoromethyl)-1H-pyrazole(SALTDATA: FREE) is employed in materials science for the development of novel polymers and additives, taking advantage of its chemical properties to improve material performance and create innovative products with specific applications.
Used in Research Applications:
3,5-bis(difluoromethyl)-1H-pyrazole(SALTDATA: FREE) serves as a valuable compound in research settings, where its diverse biological activities, such as antimicrobial, antifungal, and pesticidal properties, are explored for potential new discoveries and applications in various scientific fields.

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Downstream Products

• 1046454-44-7 4-bromo-3,5-bis(difluoromethyl)-1H-pyrazole 
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Relevant academic research and scientific papers

A Major Advance in the Synthesis of Fluoroalkyl Pyrazoles: Tuneable Regioselectivity and Broad Substitution Patterns

A novel approach towards highly functionalized fluoroalkyl pyrazoles was developed by using fluoroalkyl amino reagents in combination with a variety of fluorinated ketimines. Tuneable introduction of fluoroalkyl groups in the 3- and 5-positions was possible by using vinamidinium intermediates or the corresponding enamino ketones after hydrolysis. These high-value building blocks can give rise to a large number of analogues for bioactivity screening and discovering new heterocyclic bioactive ingredients in various life science fields.

Method for the production of 3,5-bis(fluoroalkyl) pyrazole derivatives

The invention relates to a method for producing 3,5-bis(fluoroalkyl) pyrazole derivatives and to the use thereof for producing fungicides. Also claimed are intermediates of formulae (IV) and (III).

METHOD FOR THE PRODUCTION OF 3,5-BIS(FLUOROALKYL)PYRAZOLE DERIVATIVES

The present invention describes a novel method for preparing 3,5-bis(fluoroalkyl)pyrazole derivatives.

PROCESS FOR PREPARING 3,5-BIS(HALOALKYL)PYRAZOLE DERIVATIVES VIA ACYLATION OF HYDRAZONES

Process for preparing 3,5-bis(haloalkyl)pyrazole derivatives of the formula (I), via acylation of Hydrazones.

PROCESS FOR PREPARING 3,5-BIS(HALOALKYL)PYRAZOLES VIA ACYLATION OF KETIMINES

The present invention relates to a novel process for preparing 3,5-bis(haloalkyl)pyrazole derivatives of the formula (Ia) and (Ib), via acylation of ketimines.

PROCESS FOR PREPARING 3,5-BIS(HALOALKYL)PYRAZOLE DERIVATIVES FROM α,α-DIHALOAMINES AND KETIMINES

Process for preparine3,5-bis(haloalkyl)pyrazolederivatives from a,a-dihaloamines and ketimines The present invention relates to a novel process for preparing 3,5-bis(haloalkyl)pyrazole derivatives from a,a-dihaloamines and ketimines. Intermedaites used in the process are also claimed.

A General Approach towards NH-Pyrazoles That Bear Diverse Fluoroalkyl Groups by Means of Fluorinated Iminium Salts

A new and general approach to important fluoroalkyl-substituted pyrazoles has been developed. The approach is based on the use of fluoroalkyl amino reagents and their Lewis acid activation to form a fluoroalkyl iminium salt that acts as a formal "fluoroacyl transfer reagent". Their interaction with readily available fluoroalkyl azines followed by spontaneous cyclization of the formed intermediates under acidic conditions leads to the formation of 3,5-disubstituted pyrazoles. The reaction is extremely versatile, high yielding, and allows quick access to pyrazoles that bear two fluoroalkyl functionalities (identical or different). These compounds are otherwise difficult to prepare. The reaction is scalable and suitable for industrial production.

PROCESS FOR PREPARING 3,5-BIS(HALOALKYL)PYRAZOLE DERIVATIVES FROM α,α-DIHALOAMINES

The present invention relates to a novel process for preparing 3,5-bis(haloalkyl)pyrazole derivatives.

PROCESS FOR PREPARING 3,5-BIS(FLUOROALKYL)PYRAZOLE DERIVATIVES FROM α,α-DIHALOAMINES

The present invention relates to a novel process for preparing 3,5-bis(fluoroalkyl)pyrazole derivatives from α,α-dihaloamines.

PROCESS FOR THE PREPARATION OF BIS-DIHALOALKYL PYRAZOLES

The present invention relates to a process for the preparation of bisdihaloalkyl pyrazoles of formula (V) starting from diketones and acylhalides reacted with a Lewis acid, and a subsequent reaction with a substituted hydrazine.