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4-Hydroxy-benzaldehyde 4-m-tolyl-thiosemicarbazone is a chemical compound with the molecular formula C15H14N2OS. It is a derivative of benzaldehyde, featuring a hydroxyl group at the 4-position and a thiosemicarbazone moiety attached to the aldehyde group. The 4-m-tolyl-thiosemicarbazone part of the molecule consists of a tolyl group (a methyl group attached to the meta position of a phenyl ring) and a thiosemicarbazone functional group, which is a heterocyclic compound formed by the condensation of a hydrazine derivative with a carbonyl compound. 4-hydroxy-benzaldehyde 4-m-tolyl-thiosemicarbazone is of interest in the field of coordination chemistry, as it can act as a ligand in the formation of metal complexes. It is also studied for its potential applications in various fields, including pharmaceuticals and materials science, due to its unique structure and reactivity.

7762-92-7

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7762-92-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 7762-92-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,7,6 and 2 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 7762-92:
(6*7)+(5*7)+(4*6)+(3*2)+(2*9)+(1*2)=127
127 % 10 = 7
So 7762-92-7 is a valid CAS Registry Number.

7762-92-7Relevant academic research and scientific papers

Synthesis and Ribonucleotide reductase inhibitory activity of thiosemicarbazones

Krishnan, Kesavan,Prathiba, Kumari,Jayaprakash, Venkatesan,Basu, Arijit,Mishra, Nibha,Zhou, Bingsen,Hu, Shuya,Yen, Yun

supporting information; experimental part, p. 6248 - 6250 (2009/08/07)

Ribonucleotide reductase (RR) is an important therapeutic target for anticancer drugs. The structure of human RR features a 1:1 complex of two homodimeric subunits, hRRM1 and hRRM2. Prokaryotically expressed and highly purified recombinant human RR subunits, hRRM1 and hRRM2, were used for holoenzyme-based [3H]CDP reduction in vitro assay. Ten new thiosemicarbazones (7-16) were synthesized and screened for their RR inhibitory activity. Two thiosemicarbazones derived from p-hydroxy benzaldehyde (9 and 10) were found to be active but less potent than the standard, Hydroxyurea (HU). Guided by the activity of compounds 9 and 10, 11 new thiosemicarbazones (17-27) derived from p-hydroxy benzaldehyde were prepared and screened for their RR inhibitory activity. All the 11 compounds were more potent than HU.

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